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Literature summary extracted from

  • Salazar, E.; Bank, E.M.; Ramsey, N.; Hess, K.C.; Deitsch, K.W.; Levin, L.R.; Buck, J.
    Characterization of Plasmodium falciparum adenylyl cyclase-beta and its role in erythrocytic stage parasites (2012), PLoS ONE, 7, e39769.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
4.6.1.1 medicine isoform ACbeta represents a potential target for development of safe and effective antimalarial therapeutics Plasmodium falciparum

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.6.1.1 expressed in Escherichia coli Top10 cells Plasmodium falciparum

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.6.1.1 2-hydroxyestradiol
-
 Plasmodium falciparum
4.6.1.1 KH7 potent, specific inhibitor Plasmodium falciparum

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.6.1.1 Mn2+ optimum activity at 10 mM Plasmodium falciparum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.6.1.1 ATP Plasmodium falciparum
-
 3',5'-cyclic AMP + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.1 Plasmodium falciparum
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.6.1.1 glutathione Sepharose, column chromatography and Superdex G-25 gel filtration Plasmodium falciparum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.6.1.1 ATP
-
 Plasmodium falciparum 3',5'-cyclic AMP + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.6.1.1 ACbeta
-
 Plasmodium falciparum
4.6.1.1 adenylyl cyclase-beta
-
 Plasmodium falciparum

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.6.1.1 7.5
-
-
 Plasmodium falciparum

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
4.6.1.1 0.005
-
 at pH 7.5 and 37°C Plasmodium falciparum KH7
4.6.1.1 0.008
-
 at pH 7.5 and 37°C Plasmodium falciparum 2-hydroxyestradiol

General Information

EC Number General Information Comment Organism
4.6.1.1 physiological function adenylyl cyclase activity is required in early-mid erythrocytic stages and functions as the parasite's pH sensor during growth inside red blood cells Plasmodium falciparum