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Literature summary extracted from

  • MacDonald, C.A.; Bushnell, E.A.; Gauld, J.W.; Boyd, R.J.
    The catalytic formation of leukotriene C4: a critical step in inflammatory processes (2014), Phys. Chem. Chem. Phys., 16, 16284-16289.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.4.1.20 membrane a nuclear membrane enzyme Homo sapiens 16020
-
4.4.1.20 nucleus a nuclear membrane enzyme Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.4.1.20 leukotriene A4 + glutathione Homo sapiens
-
 leukotriene C4 a cysteinyl leukotriene ?

Organism

EC Number Organism UniProt Comment Textmining
4.4.1.20 Homo sapiens
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
4.4.1.20 leukotriene C4 = leukotriene A4 + glutathione the thiolate of glutathione acts as a nucleophile attacking C6 of leukotriene A4 forming a S-C6 bond, a proton is transferred from the guanidinium of Arg31 to the epoxide ring oxygen resulting in opening of the epoxide ring and stabilization of the LTC4 product complex. The tail-to-head orientation appears to be the most likely substrate orientation Homo sapiens
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.4.1.20 leukotriene A4 + glutathione
-
 Homo sapiens leukotriene C4 a cysteinyl leukotriene ?
4.4.1.20 leukotriene A4 + glutathione mechanism of leukotriene A4 binding, docking and molecular dynamics simulations using the enzyme crystal structure, PDB ID 2PNO, overview Homo sapiens leukotriene C4
-
 ?

Subunits

EC Number Subunits Comment Organism
4.4.1.20 trimer the enzyme exists as a trimer, where the active site is formed at the interface of two of the three monomers Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
4.4.1.20 leukotriene C4 synthase
-
 Homo sapiens
4.4.1.20 LTC4S
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
4.4.1.20 physiological function leukotrienes are a family of drug-like molecules involved in the pathobiology of bronchial asthma and are responsible for smooth muscle contraction Homo sapiens