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Literature summary extracted from

  • Khedri, Z.; Li, Y.; Cao, H.; Qu, J.; Yu, H.; Muthana, M.M.; Chen, X.
    Synthesis of selective inhibitors against V. cholerae sialidase and human cytosolic sialidase NEU2 (2012), Org. Biomol. Chem., 10, 6112-6120.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.18 2,6-anhydro-9-azido-3,5,9-trideoxy-5-(2-hydroxyacetamido)-D-glycero-D-galacto-non-2-enonic acid
-
 Clostridium perfringens
3.2.1.18 2,6-anhydro-9-azido-3,5,9-trideoxy-5-(2-hydroxyacetamido)-D-glycero-D-galacto-non-2-enonic acid
-
 Homo sapiens
3.2.1.18 2,6-anhydro-9-azido-3,5,9-trideoxy-5-(2-hydroxyacetamido)-D-glycero-D-galacto-non-2-enonic acid
-
 Salmonella enterica subsp. enterica serovar Typhimurium
3.2.1.18 2,6-anhydro-9-azido-3,5,9-trideoxy-5-(2-hydroxyacetamido)-D-glycero-D-galacto-non-2-enonic acid
-
 Streptococcus pneumoniae
3.2.1.18 2,6-anhydro-9-azido-3,5,9-trideoxy-5-(2-hydroxyacetamido)-D-glycero-D-galacto-non-2-enonic acid
-
 Vibrio cholerae
3.2.1.18 2,6-anhydro-9-azido-5-(2-azidoacetamido)-3,5,9-trideoxy-D-glycero-D-galacto-non-2-enonic acid
-
 Clostridium perfringens
3.2.1.18 2,6-anhydro-9-azido-5-(2-azidoacetamido)-3,5,9-trideoxy-D-glycero-D-galacto-non-2-enonic acid
-
 Homo sapiens
3.2.1.18 2,6-anhydro-9-azido-5-(2-azidoacetamido)-3,5,9-trideoxy-D-glycero-D-galacto-non-2-enonic acid
-
 Salmonella enterica subsp. enterica serovar Typhimurium
3.2.1.18 2,6-anhydro-9-azido-5-(2-azidoacetamido)-3,5,9-trideoxy-D-glycero-D-galacto-non-2-enonic acid
-
 Streptococcus pneumoniae
3.2.1.18 2,6-anhydro-9-azido-5-(2-azidoacetamido)-3,5,9-trideoxy-D-glycero-D-galacto-non-2-enonic acid
-
 Vibrio cholerae
3.2.1.18 2-deoxy-2,3-dehydro-N-acetylneuraminic acid
-
 Clostridium perfringens
3.2.1.18 2-deoxy-2,3-dehydro-N-acetylneuraminic acid
-
 Homo sapiens
3.2.1.18 2-deoxy-2,3-dehydro-N-acetylneuraminic acid
-
 Salmonella enterica subsp. enterica serovar Typhimurium
3.2.1.18 2-deoxy-2,3-dehydro-N-acetylneuraminic acid
-
 Streptococcus pneumoniae
3.2.1.18 2-deoxy-2,3-dehydro-N-acetylneuraminic acid
-
 Vibrio cholerae
3.2.1.18 5-acetamido-2,6-anhydro-3,5-dideoxy-9-O-methyl-D-glycero-D-galacto-non-2-enonic acid
-
 Clostridium perfringens
3.2.1.18 5-acetamido-2,6-anhydro-3,5-dideoxy-9-O-methyl-D-glycero-D-galacto-non-2-enonic acid
-
 Homo sapiens
3.2.1.18 5-acetamido-2,6-anhydro-3,5-dideoxy-9-O-methyl-D-glycero-D-galacto-non-2-enonic acid
-
 Salmonella enterica subsp. enterica serovar Typhimurium
3.2.1.18 5-acetamido-2,6-anhydro-3,5-dideoxy-9-O-methyl-D-glycero-D-galacto-non-2-enonic acid
-
 Streptococcus pneumoniae
3.2.1.18 5-acetamido-2,6-anhydro-3,5-dideoxy-9-O-methyl-D-glycero-D-galacto-non-2-enonic acid
-
 Vibrio cholerae
3.2.1.18 5-acetamido-2,6-anhydro-9-azido-3,5,9-trideoxy-D-glycero-D-galacto-non-2-enonic acid
-
 Clostridium perfringens
3.2.1.18 5-acetamido-2,6-anhydro-9-azido-3,5,9-trideoxy-D-glycero-D-galacto-non-2-enonic acid
-
 Homo sapiens
3.2.1.18 5-acetamido-2,6-anhydro-9-azido-3,5,9-trideoxy-D-glycero-D-galacto-non-2-enonic acid
-
 Salmonella enterica subsp. enterica serovar Typhimurium
3.2.1.18 5-acetamido-2,6-anhydro-9-azido-3,5,9-trideoxy-D-glycero-D-galacto-non-2-enonic acid
-
 Streptococcus pneumoniae
3.2.1.18 5-acetamido-2,6-anhydro-9-azido-3,5,9-trideoxy-D-glycero-D-galacto-non-2-enonic acid
-
 Vibrio cholerae
3.2.1.18 5-acetamido-9-aminopropyl-2,6-anhydro-3,5,9-trideoxy-D-glycero-D-galacto-non-2-enonic acid
-
 Clostridium perfringens
3.2.1.18 5-acetamido-9-aminopropyl-2,6-anhydro-3,5,9-trideoxy-D-glycero-D-galacto-non-2-enonic acid
-
 Homo sapiens
3.2.1.18 5-acetamido-9-aminopropyl-2,6-anhydro-3,5,9-trideoxy-D-glycero-D-galacto-non-2-enonic acid
-
 Salmonella enterica subsp. enterica serovar Typhimurium
3.2.1.18 5-acetamido-9-aminopropyl-2,6-anhydro-3,5,9-trideoxy-D-glycero-D-galacto-non-2-enonic acid
-
 Streptococcus pneumoniae
3.2.1.18 5-acetamido-9-aminopropyl-2,6-anhydro-3,5,9-trideoxy-D-glycero-D-galacto-non-2-enonic acid
-
 Vibrio cholerae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.2.1.18 cytosol
-
 Homo sapiens 5829
-

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.18 Clostridium perfringens P10481
-
-
3.2.1.18 Homo sapiens Q9Y3R4
-
-
3.2.1.18 Salmonella enterica subsp. enterica serovar Typhimurium P29768
-
-
3.2.1.18 Streptococcus pneumoniae
-
-
-
3.2.1.18 Vibrio cholerae P0C6E9
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.18 Neu5Acalpha(2->3)Galbeta-4-nitrophenyl + H2O
-
 Streptococcus pneumoniae ?
-
 ?
3.2.1.18 Neu5Acalpha(2->3)Galbeta-4-nitrophenyl + H2O
-
 Homo sapiens ?
-
 ?
3.2.1.18 Neu5Acalpha(2->3)Galbeta-4-nitrophenyl + H2O
-
 Clostridium perfringens ?
-
 ?
3.2.1.18 Neu5Acalpha(2->3)Galbeta-4-nitrophenyl + H2O
-
 Vibrio cholerae ?
-
 ?
3.2.1.18 Neu5Acalpha(2->3)Galbeta-4-nitrophenyl + H2O
-
 Salmonella enterica subsp. enterica serovar Typhimurium ?
-
 ?
3.2.1.18 Neu5Acalpha(2->6)Galbeta4-nitrophenyl + H2O
-
 Streptococcus pneumoniae ?
-
 ?
3.2.1.18 Neu5Acalpha(2->6)Galbeta4-nitrophenyl + H2O
-
 Homo sapiens ?
-
 ?
3.2.1.18 Neu5Acalpha(2->6)Galbeta4-nitrophenyl + H2O
-
 Clostridium perfringens ?
-
 ?
3.2.1.18 Neu5Acalpha(2->6)Galbeta4-nitrophenyl + H2O
-
 Vibrio cholerae ?
-
 ?
3.2.1.18 Neu5Acalpha(2->6)Galbeta4-nitrophenyl + H2O
-
 Salmonella enterica subsp. enterica serovar Typhimurium ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.1.18 NEU2
-
 Homo sapiens
3.2.1.18 neuraminidase
-
 Streptococcus pneumoniae
3.2.1.18 neuraminidase
-
 Homo sapiens
3.2.1.18 neuraminidase
-
 Clostridium perfringens
3.2.1.18 neuraminidase
-
 Vibrio cholerae
3.2.1.18 neuraminidase
-
 Salmonella enterica subsp. enterica serovar Typhimurium
3.2.1.18 sialidase
-
 Streptococcus pneumoniae
3.2.1.18 sialidase
-
 Homo sapiens
3.2.1.18 sialidase
-
 Clostridium perfringens
3.2.1.18 sialidase
-
 Vibrio cholerae
3.2.1.18 sialidase
-
 Salmonella enterica subsp. enterica serovar Typhimurium

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.2.1.18 0.0086
-
 with Neu5Acalpha(2->3)Galbeta-4-nitrophenyl as substrate, at pH 5.0 and 37°C Vibrio cholerae 2-deoxy-2,3-dehydro-N-acetylneuraminic acid
3.2.1.18 0.0087
-
 with Neu5Acalpha(2->6)Galbeta4-nitrophenyl as substrate, at pH 5.0 and 37°C Vibrio cholerae 5-acetamido-2,6-anhydro-9-azido-3,5,9-trideoxy-D-glycero-D-galacto-non-2-enonic acid
3.2.1.18 0.01
-
 with Neu5Acalpha(2->6)Galbeta4-nitrophenyl as substrate, at pH 5.0 and 37°C Vibrio cholerae 2-deoxy-2,3-dehydro-N-acetylneuraminic acid
3.2.1.18 0.013
-
 with Neu5Acalpha(2->3)Galbeta-4-nitrophenyl as substrate, at pH 5.0 and 37°C Homo sapiens 2,6-anhydro-9-azido-5-(2-azidoacetamido)-3,5,9-trideoxy-D-glycero-D-galacto-non-2-enonic acid
3.2.1.18 0.013
-
 with Neu5Acalpha(2->3)Galbeta-4-nitrophenyl as substrate, at pH 5.0 and 37°C Vibrio cholerae 5-acetamido-2,6-anhydro-3,5-dideoxy-9-O-methyl-D-glycero-D-galacto-non-2-enonic acid
3.2.1.18 0.013
-
 with Neu5Acalpha(2->3)Galbeta-4-nitrophenyl as substrate, at pH 5.0 and 37°C Salmonella enterica subsp. enterica serovar Typhimurium 5-acetamido-2,6-anhydro-3,5-dideoxy-9-O-methyl-D-glycero-D-galacto-non-2-enonic acid
3.2.1.18 0.013
-
 with Neu5Acalpha(2->6)Galbeta4-nitrophenyl as substrate, at pH 5.0 and 37°C Clostridium perfringens 2-deoxy-2,3-dehydro-N-acetylneuraminic acid
3.2.1.18 0.013
-
 with Neu5Acalpha(2->6)Galbeta4-nitrophenyl as substrate, at pH 5.0 and 37°C Vibrio cholerae 2,6-anhydro-9-azido-3,5,9-trideoxy-5-(2-hydroxyacetamido)-D-glycero-D-galacto-non-2-enonic acid
3.2.1.18 0.013
-
 with Neu5Acalpha(2->6)Galbeta4-nitrophenyl as substrate, at pH 5.0 and 37°C Homo sapiens 2,6-anhydro-9-azido-5-(2-azidoacetamido)-3,5,9-trideoxy-D-glycero-D-galacto-non-2-enonic acid
3.2.1.18 0.014
-
 with Neu5Acalpha(2->3)Galbeta-4-nitrophenyl as substrate, at pH 5.0 and 37°C Vibrio cholerae 2,6-anhydro-9-azido-5-(2-azidoacetamido)-3,5,9-trideoxy-D-glycero-D-galacto-non-2-enonic acid
3.2.1.18 0.018
-
 with Neu5Acalpha(2->3)Galbeta-4-nitrophenyl as substrate, at pH 5.0 and 37°C Homo sapiens 2-deoxy-2,3-dehydro-N-acetylneuraminic acid
3.2.1.18 0.018
-
 with Neu5Acalpha(2->3)Galbeta-4-nitrophenyl as substrate, at pH 5.0 and 37°C Vibrio cholerae 2,6-anhydro-9-azido-3,5,9-trideoxy-5-(2-hydroxyacetamido)-D-glycero-D-galacto-non-2-enonic acid
3.2.1.18 0.02
-
 with Neu5Acalpha(2->3)Galbeta-4-nitrophenyl as substrate, at pH 5.0 and 37°C Clostridium perfringens 2-deoxy-2,3-dehydro-N-acetylneuraminic acid
3.2.1.18 0.02
-
 with Neu5Acalpha(2->3)Galbeta-4-nitrophenyl as substrate, at pH 5.0 and 37°C Salmonella enterica subsp. enterica serovar Typhimurium 2-deoxy-2,3-dehydro-N-acetylneuraminic acid
3.2.1.18 0.02
-
 with Neu5Acalpha(2->3)Galbeta-4-nitrophenyl as substrate, at pH 5.0 and 37°C Vibrio cholerae 5-acetamido-2,6-anhydro-9-azido-3,5,9-trideoxy-D-glycero-D-galacto-non-2-enonic acid
3.2.1.18 0.021
-
 with Neu5Acalpha(2->3)Galbeta-4-nitrophenyl as substrate, at pH 5.0 and 37°C Salmonella enterica subsp. enterica serovar Typhimurium 5-acetamido-2,6-anhydro-9-azido-3,5,9-trideoxy-D-glycero-D-galacto-non-2-enonic acid
3.2.1.18 0.031
-
 with Neu5Acalpha(2->6)Galbeta4-nitrophenyl as substrate, at pH 5.0 and 37°C Homo sapiens 5-acetamido-2,6-anhydro-9-azido-3,5,9-trideoxy-D-glycero-D-galacto-non-2-enonic acid
3.2.1.18 0.032
-
 with Neu5Acalpha(2->6)Galbeta4-nitrophenyl as substrate, at pH 5.0 and 37°C Homo sapiens 2-deoxy-2,3-dehydro-N-acetylneuraminic acid
3.2.1.18 0.04
-
 with Neu5Acalpha(2->6)Galbeta4-nitrophenyl as substrate, at pH 5.0 and 37°C Clostridium perfringens 5-acetamido-2,6-anhydro-9-azido-3,5,9-trideoxy-D-glycero-D-galacto-non-2-enonic acid
3.2.1.18 0.041
-
 with Neu5Acalpha(2->6)Galbeta4-nitrophenyl as substrate, at pH 5.0 and 37°C Homo sapiens 5-acetamido-2,6-anhydro-3,5-dideoxy-9-O-methyl-D-glycero-D-galacto-non-2-enonic acid
3.2.1.18 0.043
-
 with Neu5Acalpha(2->3)Galbeta-4-nitrophenyl as substrate, at pH 5.0 and 37°C Homo sapiens 5-acetamido-2,6-anhydro-9-azido-3,5,9-trideoxy-D-glycero-D-galacto-non-2-enonic acid
3.2.1.18 0.059
-
 with Neu5Acalpha(2->3)Galbeta-4-nitrophenyl as substrate, at pH 5.0 and 37°C Clostridium perfringens 5-acetamido-2,6-anhydro-9-azido-3,5,9-trideoxy-D-glycero-D-galacto-non-2-enonic acid
3.2.1.18 0.11
-
 with Neu5Acalpha(2->6)Galbeta4-nitrophenyl as substrate, at pH 5.0 and 37°C Vibrio cholerae 2,6-anhydro-9-azido-5-(2-azidoacetamido)-3,5,9-trideoxy-D-glycero-D-galacto-non-2-enonic acid
3.2.1.18 0.12
-
 with Neu5Acalpha(2->6)Galbeta4-nitrophenyl as substrate, at pH 5.0 and 37°C Vibrio cholerae 5-acetamido-2,6-anhydro-3,5-dideoxy-9-O-methyl-D-glycero-D-galacto-non-2-enonic acid
3.2.1.18 0.15
-
 with Neu5Acalpha(2->3)Galbeta-4-nitrophenyl as substrate, at pH 5.0 and 37°C Homo sapiens 2,6-anhydro-9-azido-3,5,9-trideoxy-5-(2-hydroxyacetamido)-D-glycero-D-galacto-non-2-enonic acid
3.2.1.18 0.19
-
 with Neu5Acalpha(2->6)Galbeta4-nitrophenyl as substrate, at pH 5.0 and 37°C Homo sapiens 2,6-anhydro-9-azido-3,5,9-trideoxy-5-(2-hydroxyacetamido)-D-glycero-D-galacto-non-2-enonic acid
3.2.1.18 0.31
-
 with Neu5Acalpha(2->6)Galbeta4-nitrophenyl as substrate, at pH 5.0 and 37°C Clostridium perfringens 5-acetamido-2,6-anhydro-3,5-dideoxy-9-O-methyl-D-glycero-D-galacto-non-2-enonic acid
3.2.1.18 0.46
-
 with Neu5Acalpha(2->3)Galbeta-4-nitrophenyl as substrate, at pH 5.0 and 37°C Clostridium perfringens 5-acetamido-2,6-anhydro-3,5-dideoxy-9-O-methyl-D-glycero-D-galacto-non-2-enonic acid
3.2.1.18 1
-
 IC50 above 1.0 mM, with Neu5Acalpha(2->3)Galbeta-4-nitrophenyl as substrate, at pH 5.0 and 37°C Streptococcus pneumoniae 2,6-anhydro-9-azido-5-(2-azidoacetamido)-3,5,9-trideoxy-D-glycero-D-galacto-non-2-enonic acid
3.2.1.18 1
-
 IC50 above 1.0 mM, with Neu5Acalpha(2->3)Galbeta-4-nitrophenyl as substrate, at pH 5.0 and 37°C Clostridium perfringens 5-acetamido-9-aminopropyl-2,6-anhydro-3,5,9-trideoxy-D-glycero-D-galacto-non-2-enonic acid
3.2.1.18 1
-
 IC50 above 1.0 mM, with Neu5Acalpha(2->3)Galbeta-4-nitrophenyl as substrate, at pH 5.0 and 37°C Vibrio cholerae 5-acetamido-9-aminopropyl-2,6-anhydro-3,5,9-trideoxy-D-glycero-D-galacto-non-2-enonic acid
3.2.1.18 1
-
 IC50 above 1.0 mM, with Neu5Acalpha(2->6)Galbeta4-nitrophenyl as substrate, at pH 5.0 and 37°C Clostridium perfringens 5-acetamido-9-aminopropyl-2,6-anhydro-3,5,9-trideoxy-D-glycero-D-galacto-non-2-enonic acid
3.2.1.18 1
-
 IC50 above 1.0 mM, with Neu5Acalpha(2->6)Galbeta4-nitrophenyl as substrate, at pH 5.0 and 37°C Vibrio cholerae 5-acetamido-9-aminopropyl-2,6-anhydro-3,5,9-trideoxy-D-glycero-D-galacto-non-2-enonic acid
3.2.1.18 1.1
-
 with Neu5Acalpha(2->3)Galbeta-4-nitrophenyl as substrate, at pH 5.0 and 37°C Homo sapiens 5-acetamido-2,6-anhydro-3,5-dideoxy-9-O-methyl-D-glycero-D-galacto-non-2-enonic acid
3.2.1.18 1.2
-
 with Neu5Acalpha(2->6)Galbeta4-nitrophenyl as substrate, at pH 5.0 and 37°C Clostridium perfringens 2,6-anhydro-9-azido-5-(2-azidoacetamido)-3,5,9-trideoxy-D-glycero-D-galacto-non-2-enonic acid
3.2.1.18 1.4
-
 with Neu5Acalpha(2->6)Galbeta4-nitrophenyl as substrate, at pH 5.0 and 37°C Clostridium perfringens 2,6-anhydro-9-azido-3,5,9-trideoxy-5-(2-hydroxyacetamido)-D-glycero-D-galacto-non-2-enonic acid
3.2.1.18 1.6
-
 with Neu5Acalpha(2->3)Galbeta-4-nitrophenyl as substrate, at pH 5.0 and 37°C Clostridium perfringens 2,6-anhydro-9-azido-5-(2-azidoacetamido)-3,5,9-trideoxy-D-glycero-D-galacto-non-2-enonic acid
3.2.1.18 1.9
-
 with Neu5Acalpha(2->3)Galbeta-4-nitrophenyl as substrate, at pH 5.0 and 37°C Clostridium perfringens 2,6-anhydro-9-azido-3,5,9-trideoxy-5-(2-hydroxyacetamido)-D-glycero-D-galacto-non-2-enonic acid
3.2.1.18 2.3
-
 with Neu5Acalpha(2->3)Galbeta-4-nitrophenyl as substrate, at pH 5.0 and 37°C Salmonella enterica subsp. enterica serovar Typhimurium 5-acetamido-9-aminopropyl-2,6-anhydro-3,5,9-trideoxy-D-glycero-D-galacto-non-2-enonic acid
3.2.1.18 2.4
-
 with Neu5Acalpha(2->6)Galbeta4-nitrophenyl as substrate, at pH 5.0 and 37°C Homo sapiens 5-acetamido-9-aminopropyl-2,6-anhydro-3,5,9-trideoxy-D-glycero-D-galacto-non-2-enonic acid
3.2.1.18 3
-
 with Neu5Acalpha(2->3)Galbeta-4-nitrophenyl as substrate, at pH 5.0 and 37°C Streptococcus pneumoniae 5-acetamido-2,6-anhydro-3,5-dideoxy-9-O-methyl-D-glycero-D-galacto-non-2-enonic acid
3.2.1.18 3.3
-
 with Neu5Acalpha(2->3)Galbeta-4-nitrophenyl as substrate, at pH 5.0 and 37°C Streptococcus pneumoniae 5-acetamido-2,6-anhydro-9-azido-3,5,9-trideoxy-D-glycero-D-galacto-non-2-enonic acid
3.2.1.18 3.7
-
 with Neu5Acalpha(2->3)Galbeta-4-nitrophenyl as substrate, at pH 5.0 and 37°C Streptococcus pneumoniae 2-deoxy-2,3-dehydro-N-acetylneuraminic acid
3.2.1.18 5.4
-
 with Neu5Acalpha(2->3)Galbeta-4-nitrophenyl as substrate, at pH 5.0 and 37°C Streptococcus pneumoniae 5-acetamido-9-aminopropyl-2,6-anhydro-3,5,9-trideoxy-D-glycero-D-galacto-non-2-enonic acid
3.2.1.18 10
-
 IC50 above 10 mM, with Neu5Acalpha(2->3)Galbeta-4-nitrophenyl as substrate, at pH 5.0 and 37°C Streptococcus pneumoniae 2,6-anhydro-9-azido-3,5,9-trideoxy-5-(2-hydroxyacetamido)-D-glycero-D-galacto-non-2-enonic acid
3.2.1.18 10
-
 IC50 above 10 mM, with Neu5Acalpha(2->3)Galbeta-4-nitrophenyl as substrate, at pH 5.0 and 37°C Salmonella enterica subsp. enterica serovar Typhimurium 2,6-anhydro-9-azido-3,5,9-trideoxy-5-(2-hydroxyacetamido)-D-glycero-D-galacto-non-2-enonic acid
3.2.1.18 10
-
 IC50 above 10 mM, with Neu5Acalpha(2->3)Galbeta-4-nitrophenyl as substrate, at pH 5.0 and 37°C Homo sapiens 5-acetamido-9-aminopropyl-2,6-anhydro-3,5,9-trideoxy-D-glycero-D-galacto-non-2-enonic acid
3.2.1.18 16
-
 with Neu5Acalpha(2->3)Galbeta-4-nitrophenyl as substrate, at pH 5.0 and 37°C Salmonella enterica subsp. enterica serovar Typhimurium 2,6-anhydro-9-azido-5-(2-azidoacetamido)-3,5,9-trideoxy-D-glycero-D-galacto-non-2-enonic acid