BRENDA - Enzyme Database show

The first identification of lysine malonylation substrates and its regulatory enzyme

Peng, C.; Lu, Z.; Xie, Z.; Cheng, Z.; Chen, Y.; Tan, M.; Luo, H.; Zhang, Y.; He, W.; Yang, K.; Zwaans, B.M.; Tishkoff, D.; Ho, L.; Lombard, D.; He, T.C.; Dai, J.; Verdin, E.; Ye, Y.; Zhao, Y.; Mol. Cell. Proteomics 10, 0000 (2011)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.3.1.B43
nicotinamide
inhibits demalonylation and desuccinylation activity
Mus musculus
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.3.1.B43
NAD+ + [protein]-N6-malonyl-L-lysine
Mus musculus
-
nicotinamide + [protein]-L-lysine + 2'-O-malonyl-ADP-ribose
-
-
?
2.3.1.B43
NAD+ + [protein]-N6-succinyl-L-lysine
Mus musculus
-
nicotinamide + [protein]-L-lysine + 2'-O-succinyl-ADP-ribose
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.3.1.B43
Mus musculus
Q8K2C6
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.1.B43
additional information
Sirt5 shows negligible activity toward lysine deacetylation
730383
Mus musculus
?
-
-
-
-
2.3.1.B43
NAD+ + AFNQG(N6-malonyl)KIFK
-
730383
Mus musculus
nicotinamide + AFNQGKIFK + 2'-O-malonyl-ADP-ribose
-
-
-
?
2.3.1.B43
NAD+ + AYVDDTPAEQM(N6-malonyl)KAER
-
730383
Mus musculus
nicotinamide + AYVDDTPAEQMKAER + 2'-O-malonyl-ADP-ribose
-
-
-
?
2.3.1.B43
NAD+ + DSYVGDEAQSDSYVGDEAQS(N6-malonyl)KR
-
730383
Mus musculus
nicotinamide + DSYVGDEAQSDSYVGDEAQSKR + 2'-O-malonyl-ADP-ribose
-
-
-
?
2.3.1.B43
NAD+ + ETGVDLT(N6-succinyl)KDNMALQR
-
730383
Mus musculus
nicotinamide + ETGVDLTKDNMALQR + 2'-O-succinyl-ADP-ribose
-
-
-
?
2.3.1.B43
NAD+ + IEEELGS(N6-malonyl)KAK
-
730383
Mus musculus
nicotinamide + IEEELGSKAK + 2'-O-malonyl-ADP-ribose
-
-
-
?
2.3.1.B43
NAD+ + SQG(N6-succinyl)KVLQATVV
-
730383
Mus musculus
nicotinamide + SQGKVLQATVV + 2'-O-succinyl-ADP-ribose
-
-
-
?
2.3.1.B43
NAD+ + TAIG(N6-malonyl)KAGYTDK
-
730383
Mus musculus
nicotinamide + TAIGKAGYTDK + 2'-O-malonyl-ADP-ribose
-
-
-
?
2.3.1.B43
NAD+ + VLLPEYGGT(N6-succinyl)KVVLDDK
-
730383
Mus musculus
nicotinamide + VLLPEYGGTKVVLDDK + 2'-O-succinyl-ADP-ribose
-
-
-
?
2.3.1.B43
NAD+ + [protein]-N6-malonyl-L-lysine
-
730383
Mus musculus
nicotinamide + [protein]-L-lysine + 2'-O-malonyl-ADP-ribose
-
-
-
?
2.3.1.B43
NAD+ + [protein]-N6-succinyl-L-lysine
-
730383
Mus musculus
nicotinamide + [protein]-L-lysine + 2'-O-succinyl-ADP-ribose
-
-
-
?
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.3.1.B43
nicotinamide
inhibits demalonylation and desuccinylation activity
Mus musculus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.3.1.B43
NAD+ + [protein]-N6-malonyl-L-lysine
Mus musculus
-
nicotinamide + [protein]-L-lysine + 2'-O-malonyl-ADP-ribose
-
-
?
2.3.1.B43
NAD+ + [protein]-N6-succinyl-L-lysine
Mus musculus
-
nicotinamide + [protein]-L-lysine + 2'-O-succinyl-ADP-ribose
-
-
?
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.1.B43
additional information
Sirt5 shows negligible activity toward lysine deacetylation
730383
Mus musculus
?
-
-
-
-
2.3.1.B43
NAD+ + AFNQG(N6-malonyl)KIFK
-
730383
Mus musculus
nicotinamide + AFNQGKIFK + 2'-O-malonyl-ADP-ribose
-
-
-
?
2.3.1.B43
NAD+ + AYVDDTPAEQM(N6-malonyl)KAER
-
730383
Mus musculus
nicotinamide + AYVDDTPAEQMKAER + 2'-O-malonyl-ADP-ribose
-
-
-
?
2.3.1.B43
NAD+ + DSYVGDEAQSDSYVGDEAQS(N6-malonyl)KR
-
730383
Mus musculus
nicotinamide + DSYVGDEAQSDSYVGDEAQSKR + 2'-O-malonyl-ADP-ribose
-
-
-
?
2.3.1.B43
NAD+ + ETGVDLT(N6-succinyl)KDNMALQR
-
730383
Mus musculus
nicotinamide + ETGVDLTKDNMALQR + 2'-O-succinyl-ADP-ribose
-
-
-
?
2.3.1.B43
NAD+ + IEEELGS(N6-malonyl)KAK
-
730383
Mus musculus
nicotinamide + IEEELGSKAK + 2'-O-malonyl-ADP-ribose
-
-
-
?
2.3.1.B43
NAD+ + SQG(N6-succinyl)KVLQATVV
-
730383
Mus musculus
nicotinamide + SQGKVLQATVV + 2'-O-succinyl-ADP-ribose
-
-
-
?
2.3.1.B43
NAD+ + TAIG(N6-malonyl)KAGYTDK
-
730383
Mus musculus
nicotinamide + TAIGKAGYTDK + 2'-O-malonyl-ADP-ribose
-
-
-
?
2.3.1.B43
NAD+ + VLLPEYGGT(N6-succinyl)KVVLDDK
-
730383
Mus musculus
nicotinamide + VLLPEYGGTKVVLDDK + 2'-O-succinyl-ADP-ribose
-
-
-
?
2.3.1.B43
NAD+ + [protein]-N6-malonyl-L-lysine
-
730383
Mus musculus
nicotinamide + [protein]-L-lysine + 2'-O-malonyl-ADP-ribose
-
-
-
?
2.3.1.B43
NAD+ + [protein]-N6-succinyl-L-lysine
-
730383
Mus musculus
nicotinamide + [protein]-L-lysine + 2'-O-succinyl-ADP-ribose
-
-
-
?