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Literature summary extracted from

  • Sakai, K.; Igarashi, M.; Yamamuro, D.; Ohshiro, T.; Nagashima, S.; Takahashi, M.; Enkhtuvshin, B.; Sekiya, M.; Okazak, H.; Osuga, J.I.; Ishibashi, S.
    Critical role of neutral cholesteryl ester hydrolase 1 in cholesteryl ester hydrolysis in murine macrophages (2014), J. Lipid Res., 55, 2033-2040.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.1.13 expressed in HEK-293A cells Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.13 (+)-AS115 non-selective inhibitor Mus musculus
3.1.1.13 (-)-AS115 non-selective inhibitor Mus musculus
3.1.1.13 76-0079
-
 Mus musculus
3.1.1.13 additional information not inhibited by orlistat and benzil Mus musculus
3.1.1.13 paraoxon selective inhibitor Mus musculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.1.13 50000
-
 x * 50000, SDS-PAGE Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.13 Mus musculus Q8BLF1
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.13 peritoneal macrophage
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.13 cholesteryl oleate + H2O
-
 Mus musculus cholesterol + oleic acid
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.1.13 ? x * 50000, SDS-PAGE Mus musculus

Synonyms

EC Number Synonyms Comment Organism
3.1.1.13 NCEH
-
 Mus musculus
3.1.1.13 Nceh1
-
 Mus musculus
3.1.1.13 neutral CE hydrolase 1
-
 Mus musculus
3.1.1.13 neutral cholesteryl ester hydrolase 1
-
 Mus musculus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.1.13 0.000003
-
 pH and temperature not specified in the publication Mus musculus paraoxon
3.1.1.13 0.0001
-
 pH and temperature not specified in the publication Mus musculus (-)-AS115
3.1.1.13 0.0003
-
 pH and temperature not specified in the publication Mus musculus (+)-AS115
3.1.1.13 0.0023
-
 pH and temperature not specified in the publication Mus musculus 76-0079

Expression

EC Number Organism Comment Expression
3.1.1.13 Mus musculus enzyme activity is not increased by overexpression of Ces3 additional information
3.1.1.13 Mus musculus enzyme activity is increased 24.9fold by overexpression of hormone-sensitive lipase up

General Information

EC Number General Information Comment Organism
3.1.1.13 physiological function the enzyme plays a dominant role over hormone-sensitive lipase in the hydrolysis of cholesteryl ester and subsequent cholesterol efflux in mouse peritoneal macrophages Mus musculus