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Literature summary extracted from

  • Feldman, J.L.; Baeza, J.; Denu, J.M.
    Activation of the protein deacetylase SIRT6 by long-chain fatty acids and widespread deacylation by mammalian sirtuins (2013), J. Biol. Chem., 288, 31350-31356.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.B43 NAD+ + [protein]-N6-succinyl-L-lysine Homo sapiens
-
 nicotinamide + [protein]-L-lysine + 2'-O-succinyl-ADP-ribose
-
 ?
2.3.1.286 NAD+ + [protein]-N6-succinyl-L-lysine Homo sapiens
-
 nicotinamide + [protein]-L-lysine + 2'-O-succinyl-ADP-ribose
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.B41 Homo sapiens Q8N6T7
-
-
2.3.1.B43 Homo sapiens Q9NXA8
-
-
2.3.1.286 Homo sapiens Q8IXJ6
-
-
2.3.1.286 Homo sapiens Q96EB6
-
-
2.3.1.286 Homo sapiens Q9NTG7
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.3.1.B41 NAD+ + [protein]-N6-palmitoyl-L-lysine = nicotinamide + [protein]-L-lysine + 2'-O-palmitoyl-ADP ribose the enzyme prefers long chain fatty acyl groups Homo sapiens
a
2.3.1.B43 NAD+ + [protein]-N6-succinyl-L-lysine = nicotinamide + [protein]-L-lysine + 2'-O-succinyl-ADP-ribose most efficient at catalyzing desuccinylation, medium-chain deacylation (octanoyl-, decanoyl-, dodecanoyl-) is catalyzed with lower activity Homo sapiens
a
2.3.1.286 [protein]-N6-acetyl-L-lysine + NAD+ + H2O = [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide broad specificity with respect to chain length of the acyl chain Homo sapiens
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.B41 additional information no or very low activity with QTAR(N6-acetyl)KSTGG, QTAR(N6-propionyl)KSTGG, QTAR(N6-succinyl)KSTGG, QTAR(N6-butyryl)KSTGG, QTAR(N6-crotonyl)KSTGG Homo sapiens ?
-
 ?
2.3.1.B41 NAD+ + QTAR(N6-decanoyl)KSTGG
-
 Homo sapiens nicotinamide + QTARKSTGG + 2'-O-decanoyl-ADP-ribose
-
 ?
2.3.1.B41 NAD+ + QTAR(N6-decanoyl)KSTGG myristoylated histone H3 peptide, about 60% compared to the activity with the decanoylated peptide Homo sapiens nicotinamide + QTARKSTGG + 2'-O-decanoyl-ADP-ribose
-
 ?
2.3.1.B41 NAD+ + QTAR(N6-dodecanoyl)KSTGG dodecanoylated histone H3 peptide, about 60% compared to the activity with the decanoylated peptide Homo sapiens nicotinamide + QTARKSTGG + 2'-O-dodecanoyl-ADP-ribose
-
 ?
2.3.1.B41 NAD+ + QTAR(N6-hexanoyl)KSTGG hexanoylated histone H3 peptide, about 20% compared to the activity with the decanoylated peptide Homo sapiens nicotinamide + QTARKSTGG + 2'-O-hexanoyl-ADP-ribose
-
 ?
2.3.1.B41 NAD+ + QTAR(N6-octanoyl)KSTGG octanoylated histone H3 peptide, about 50% compared to the activity with the decanoylated peptide Homo sapiens nicotinamide + QTARKSTGG + 2'-O-octanoyl-ADP-ribose
-
 ?
2.3.1.B43 NAD+ + QTAR(N6-acetyl)KSTGG acetylated histone H3 peptide, less than 10% compared to the activity with the succinylated peptide Homo sapiens nicotinamide + QTARKSTGG + 2'-O-acetyl-ADP-ribose
-
 ?
2.3.1.B43 NAD+ + QTAR(N6-decanoyl)KSTGG decanoylated histone H3 peptide, about 35% compared to the activity with the succinylated peptide Homo sapiens nicotinamide + QTARKSTGG + 2'-O-decanoyl-ADP-ribose
-
 ?
2.3.1.B43 NAD+ + QTAR(N6-dodecanoyl)KSTGG dodecanoylated histone H3 peptide, about 35% compared to the activity with the succinylated peptide Homo sapiens nicotinamide + QTARKSTGG + 2'-O-dodecanoyl-ADP-ribose
-
 ?
2.3.1.B43 NAD+ + QTAR(N6-hexanoyl)KSTGG hexanoylated histone H3 peptide, less than 10% compared to the activity with the succinylated peptide Homo sapiens nicotinamide + QTARKSTGG + 2'-O-hexanoyl-ADP-ribose
-
 ?
2.3.1.B43 NAD+ + QTAR(N6-myristoyl)KSTGG myristoylated histone H3 peptide, about 15% compared to the activity with the succinylated peptide Homo sapiens nicotinamide + QTARKSTGG + 2'-O-myristoyl-ADP-ribose
-
 ?
2.3.1.B43 NAD+ + QTAR(N6-octanoyl)KSTGG octanoylated histone H3 peptide, about 30% compared to the activity with the succinylated peptide Homo sapiens nicotinamide + QTARKSTGG + 2'-O-octanoyl-ADP-ribose
-
 ?
2.3.1.B43 NAD+ + QTAR(N6-propionyl)KSTGG propionylated histone H3 peptide, less than 10% compared to the activity with the succinylated peptide Homo sapiens nicotinamide + QTARKSTGG + 2'-O-propionyl-ADP-ribose
-
 ?
2.3.1.B43 NAD+ + QTAR(N6-succinyl)KSTGG succinylated histone H3 peptide Homo sapiens nicotinamide + QTARKSTGG + 2'-O-succinyl-ADP-ribose
-
 ?
2.3.1.B43 NAD+ + [protein]-N6-succinyl-L-lysine
-
 Homo sapiens nicotinamide + [protein]-L-lysine + 2'-O-succinyl-ADP-ribose
-
 ?
2.3.1.286 additional information no activity with the crotonylated histone H3 peptide QTAR(N6-crotonyl)KSTGG Homo sapiens ?
-
 ?
2.3.1.286 additional information no activity with the succinylated histone H3 peptide QTAR(N6-succinyl)KSTGG Homo sapiens ?
-
 ?
2.3.1.286 NAD+ + QTAR(N6-acetyl)KSTGG acetylated histone H3 peptide Homo sapiens nicotinamide + QTARKSTGG + 2'-O-acetyl-ADP-ribose
-
 ?
2.3.1.286 NAD+ + QTAR(N6-butyryl)KSTGG butyrylated histone H3 peptide Homo sapiens nicotinamide + QTARKSTGG + 2'-O-butyryl-ADP-ribose
-
 ?
2.3.1.286 NAD+ + QTAR(N6-butyryl)KSTGG butyrylated histone H3 peptide, about 20% compared to the activity with the acetylated peptide Homo sapiens nicotinamide + QTARKSTGG + 2'-O-butyryl-ADP-ribose
-
 ?
2.3.1.286 NAD+ + QTAR(N6-butyryl)KSTGG butyrylated histone H3 peptide, about 5% compared to the activity with the acetylated peptide Homo sapiens nicotinamide + QTARKSTGG + 2'-O-butyryl-ADP-ribose
-
 ?
2.3.1.286 NAD+ + QTAR(N6-crotonyl)KSTGG crotonylated histone H3 peptide, about 20% compared to the activity with the acetylated peptide Homo sapiens nicotinamide + QTARKSTGG + 2'-O-crotonyl-ADP-ribose
-
 ?
2.3.1.286 NAD+ + QTAR(N6-crotonyl)KSTGG crotonylated histone H3 peptide, about 30% compared to the activity with the acetylated or hexanoylated peptide Homo sapiens nicotinamide + QTARKSTGG + 2'-O-crotonyl-ADP-ribose
-
 ?
2.3.1.286 NAD+ + QTAR(N6-decanoyl)KSTGG decanoylated histone H3 peptide, about 50% compared to the activity with the acetylated peptide Homo sapiens nicotinamide + QTARKSTGG + 2'-O-decanoyl-ADP-ribose
-
 ?
2.3.1.286 NAD+ + QTAR(N6-decanoyl)KSTGG decanoylated histone H3 peptide, about 65% compared to the activity with the acetylated peptide Homo sapiens nicotinamide + QTARKSTGG + 2'-O-decanoyl-ADP-ribose
-
 ?
2.3.1.286 NAD+ + QTAR(N6-decanoyl)KSTGG decanoylated histone H3 peptide, about 80% compared to the activity with the acetylated or hexanoylated peptide Homo sapiens nicotinamide + QTARKSTGG + 2'-O-decanoyl-ADP-ribose
-
 ?
2.3.1.286 NAD+ + QTAR(N6-decanoyl)KSTGG myristoylated histone H3 peptide, about 50% compared to the activity with the acetylated or hexanoylated peptide Homo sapiens nicotinamide + QTARKSTGG + 2'-O-decanoyl-ADP-ribose
-
 ?
2.3.1.286 NAD+ + QTAR(N6-decanoyl)KSTGG myristoylated histone H3 peptide, about 65% compared to the activity with the acetylated or hexanoylated peptide Homo sapiens nicotinamide + QTARKSTGG + 2'-O-decanoyl-ADP-ribose
-
 ?
2.3.1.286 NAD+ + QTAR(N6-dodecanoyl)KSTGG dodecanoylated histone H3 peptide, about 30% compared to the activity with the acetylated peptide Homo sapiens nicotinamide + QTARKSTGG + 2'-O-dodecanoyl-ADP-ribose
-
 ?
2.3.1.286 NAD+ + QTAR(N6-dodecanoyl)KSTGG dodecanoylated histone H3 peptide, about 60% compared to the activity with the acetylated or hexanoylated peptide Homo sapiens nicotinamide + QTARKSTGG + 2'-O-dodecanoyl-ADP-ribose
-
 ?
2.3.1.286 NAD+ + QTAR(N6-dodecanoyl)KSTGG dodecanoylated histone H3 peptide, about 65% compared to the activity with the acetylated peptide Homo sapiens nicotinamide + QTARKSTGG + 2'-O-dodecanoyl-ADP-ribose
-
 ?
2.3.1.286 NAD+ + QTAR(N6-hexanoyl)KSTGG hexanoylated histone H3 peptide Homo sapiens nicotinamide + QTARKSTGG + 2'-O-hexanoyl-ADP-ribose
-
 ?
2.3.1.286 NAD+ + QTAR(N6-hexanoyl)KSTGG hexanoylated histone H3 peptide, about 20% compared to the activity with the acetylated peptide Homo sapiens nicotinamide + QTARKSTGG + 2'-O-hexanoyl-ADP-ribose
-
 ?
2.3.1.286 NAD+ + QTAR(N6-hexanoyl)KSTGG hexanoylated histone H3 peptide, about 40% compared to the activity with the acetylated peptide Homo sapiens nicotinamide + QTARKSTGG + 2'-O-hexanoyl-ADP-ribose
-
 ?
2.3.1.286 NAD+ + QTAR(N6-myristoyl)KSTGG myristoylated histone H3 peptide, about 45% compared to the activity with the acetylated or hexanoylated peptide Homo sapiens nicotinamide + QTARKSTGG + 2'-O-myristoyl-ADP-ribose
-
 ?
2.3.1.286 NAD+ + QTAR(N6-octanoyl)KSTGG octanoylated histone H3 peptide Homo sapiens nicotinamide + QTARKSTGG + 2'-O-octanoyl-ADP-ribose
-
 ?
2.3.1.286 NAD+ + QTAR(N6-octanoyl)KSTGG octanoylated histone H3 peptide, about 35% compared to the activity with the acetylated peptide Homo sapiens nicotinamide + QTARKSTGG + 2'-O-octanoyl-ADP-ribose
-
 ?
2.3.1.286 NAD+ + QTAR(N6-octanoyl)KSTGG octanoylated histone H3 peptide, about 55% compared to the activity with the acetylated peptide Homo sapiens nicotinamide + QTARKSTGG + 2'-O-octanoyl-ADP-ribose
-
 ?
2.3.1.286 NAD+ + QTAR(N6-palmitoyl)KSTGG myristoylated histone H3 peptide, about 30% compared to the activity with the acetylated or hexanoylated peptide Homo sapiens nicotinamide + QTARKSTGG + 2'-O-palmitoyl-ADP-ribose
-
 ?
2.3.1.286 NAD+ + QTAR(N6-propionyl)KSTGG propionylated histone H3 peptide, about 10% compared to the activity with the acetylated peptide Homo sapiens nicotinamide + QTARKSTGG + 2'-O-propionyl-ADP-ribose
-
 ?
2.3.1.286 NAD+ + QTAR(N6-propionyl)KSTGG propionylated histone H3 peptide, about 40% compared to the activity with the acetylated peptide Homo sapiens nicotinamide + QTARKSTGG + 2'-O-propionyl-ADP-ribose
-
 ?
2.3.1.286 NAD+ + QTAR(N6-propionyl)KSTGG propionylated histone H3 peptide, about 60% compared to the activity with the acetylated or hexanoylated peptide Homo sapiens nicotinamide + QTARKSTGG + 2'-O-propionyl-ADP-ribose
-
 ?
2.3.1.286 NAD+ + QTAR(N6-succinyl)KSTGG succinylated histone H3 peptide, about 10% compared to the activity with the acetylated peptide Homo sapiens nicotinamide + QTARKSTGG + 2'-O-succinyl-ADP-ribose
-
 ?
2.3.1.286 NAD+ + [protein]-N6-succinyl-L-lysine
-
 Homo sapiens nicotinamide + [protein]-L-lysine + 2'-O-succinyl-ADP-ribose
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.B41 SIRT6
-
 Homo sapiens
2.3.1.B41 sirtuin 6
-
 Homo sapiens
2.3.1.B43 SIRT5
-
 Homo sapiens
2.3.1.B43 sirtuin 5
-
 Homo sapiens
2.3.1.286 SIRT1
-
 Homo sapiens
2.3.1.286 SIRT2
-
 Homo sapiens
2.3.1.286 SIRT3
-
 Homo sapiens