EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.13.11.58 | 13S-HPODE | - |
Homo sapiens | |
4.2.1.152 | (13S)-HPODE | - |
Homo sapiens |
EC Number | Cloned (Comment) | Organism |
---|---|---|
1.13.11.58 | - |
Homo sapiens |
4.2.1.152 | - |
Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
1.13.11.58 | A451G | the mutant reacts well with arachidonic acid even in the absence of fatty acid hydroperoxides | Homo sapiens |
4.2.1.152 | A451G | unlike wild type enzyme, the mutant reacts well with arachidonic acid even in the absence of fatty acid hydroperoxides, yet only after an unusually long lag phase of about 20 min | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.13.11.58 | 0.05 | - |
9E,11Z,14Z-20:3omega6 | at pH 7.5 and 22°C | Homo sapiens |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.13.11.58 | Fe2+ | contains Fe2+ | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.13.11.58 | Homo sapiens | - |
- |
- |
4.2.1.152 | Homo sapiens | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.13.11.58 | - |
Homo sapiens |
4.2.1.152 | - |
Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.13.11.58 | (9E,11Z,14Z)-icosa-9,11,14-trienoic acid + O2 | good substrate | Homo sapiens | (9S,11Z,14Z)-9-hydroperoxyicosa-11,14-dienoic acid | - |
? | |
1.13.11.58 | AA/Lyso-PA + O2 | - |
Homo sapiens | 15-HPETE/lyso-PA + 13-HPETE/lyso-PA + 15-HPETE/lyso-PA + 11-HPETE/lyso-PA + 5-HPETE/lyso-PA | 36%, 22%, 21% and 13% yield, respectively | ? | |
1.13.11.58 | arachidonic acid + O2 | - |
Homo sapiens | 5-HPETE + 7-HPETE + 9-HPETE | 22%, 25% and 29% yield, respectively | ? | |
4.2.1.152 | (9E,11Z,14Z)-20:3omega6 | good substrate | Homo sapiens | (9S)-hydroperoxy-(10E,12E,14Z)-eicosatrienoic acid + H2O | - |
? | |
4.2.1.152 | arachidonic acid + O2 | in the absence of fatty acid hydroperoxides, the enzyme shows only weak and slow activity with arachidonic acid | Homo sapiens | 5-HPETE + 7-HPETE + 9-HPETE | 22%, 25%, and 29% yield, respectively | ? | |
4.2.1.152 | arachidonoyl-lysophosphatidic acid | - |
Homo sapiens | 15-HPETE-lysophosphatidic acid + 13-HPETE-lysophosphatidic acid + 11HPETE-lysophosphatidic acid + 5-HPETE-lysophosphatidic acid + H2O | 36%, 22%, 21%, and 13% yield, respectively | ? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.13.11.58 | eLOX3 | - |
Homo sapiens |
1.13.11.58 | epidermal lipoxygenase-3 | - |
Homo sapiens |
4.2.1.152 | eLOX3 | - |
Homo sapiens |
4.2.1.152 | epidermal lipoxygenase-3 | - |
Homo sapiens |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.13.11.58 | 1.6 | - |
9E,11Z,14Z-20:3omega6 | at pH 7.5 and 22°C | Homo sapiens |