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Literature summary extracted from

  • Kawamura, T.; Anraku, R.; Hasegawa, T.; Tomikawa, C.; Hori, H.
    Transfer RNA methyltransferases from Thermoplasma acidophilum, a thermoacidophilic archaeon (2014), Int. J. Mol. Sci., 16, 91-113.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.206
-
 Thermoplasma acidophilum
2.1.1.216
-
 Thermoplasma acidophilum
2.1.1.228
-
 Thermoplasma acidophilum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.216 4 S-adenosyl-L-methionine + guanine26 in initiator tRNAMet Thermoplasma acidophilum m2G26 and m22G26 are formed by Trm1 4 S-adenosyl-L-homocysteine + N2-dimethylguanine26 in initiator tRNAMet
-
 ?
2.1.1.216 4 S-adenosyl-L-methionine + guanine26 in prolongator tRNAMet Thermoplasma acidophilum m2G26 and m22G26 are formed by Trm1 4 S-adenosyl-L-homocysteine + N2-dimethylguanine26 in prolongator tRNAMet
-
 ?
2.1.1.216 4 S-adenosyl-L-methionine + guanine26 in tRNA Thermoplasma acidophilum G modification at position 26 is a mixture of m2G and m22G generated by Trm1 4 S-adenosyl-L-homocysteine + N2-dimethylguanine26 in tRNA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.206 Thermoplasma acidophilum
-
-
-
2.1.1.206 Thermoplasma acidophilum HO-62
-
-
-
2.1.1.216 Thermoplasma acidophilum
-
-
-
2.1.1.216 Thermoplasma acidophilum P57706
-
-
2.1.1.216 Thermoplasma acidophilum HO-62
-
-
-
2.1.1.228 Thermoplasma acidophilum
-
-
-
2.1.1.228 Thermoplasma acidophilum HO-62
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.206
-
 Thermoplasma acidophilum
2.1.1.216
-
 Thermoplasma acidophilum
2.1.1.228
-
 Thermoplasma acidophilum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.206 S-adenosyl-L-methionine + cytidine56 in elongator tRNAMet
-
 Thermoplasma acidophilum S-adenosyl-L-homocysteine + 2'-O-methylcytidine56 in elongator tRNAMet
-
 ?
2.1.1.206 S-adenosyl-L-methionine + cytidine56 in elongator tRNAMet
-
 Thermoplasma acidophilum HO-62 S-adenosyl-L-homocysteine + 2'-O-methylcytidine56 in elongator tRNAMet
-
 ?
2.1.1.206 S-adenosyl-L-methionine + cytidine56 in initiator tRNAMet
-
 Thermoplasma acidophilum S-adenosyl-L-homocysteine + 2'-O-methylcytidine56 in initiator tRNAMet
-
 ?
2.1.1.206 S-adenosyl-L-methionine + cytidine56 in initiator tRNAMet
-
 Thermoplasma acidophilum HO-62 S-adenosyl-L-homocysteine + 2'-O-methylcytidine56 in initiator tRNAMet
-
 ?
2.1.1.206 S-adenosyl-L-methionine + cytidine56 in tRNALeu(UAG)
-
 Thermoplasma acidophilum S-adenosyl-L-homocysteine + 2'-O-methylcytidine56 in tRNALeu(UAG)
-
 ?
2.1.1.206 S-adenosyl-L-methionine + cytidine56 in tRNALeu(UAG)
-
 Thermoplasma acidophilum HO-62 S-adenosyl-L-homocysteine + 2'-O-methylcytidine56 in tRNALeu(UAG)
-
 ?
2.1.1.216 2 S-adenosyl-L-methionine + guanine26 in elongator tRNAMet
-
 Thermoplasma acidophilum 2 S-adenosyl-L-homocysteine + N2-dimethylguanine26 in elongator tRNAMet
-
 ?
2.1.1.216 2 S-adenosyl-L-methionine + guanine26 in elongator tRNAMet
-
 Thermoplasma acidophilum HO-62 2 S-adenosyl-L-homocysteine + N2-dimethylguanine26 in elongator tRNAMet
-
 ?
2.1.1.216 2 S-adenosyl-L-methionine + guanine26 in initiator tRNAMet
-
 Thermoplasma acidophilum 2 S-adenosyl-L-homocysteine + N2-dimethylguanine26 in initiator tRNAMet
-
 ?
2.1.1.216 2 S-adenosyl-L-methionine + guanine26 in initiator tRNAMet
-
 Thermoplasma acidophilum HO-62 2 S-adenosyl-L-homocysteine + N2-dimethylguanine26 in initiator tRNAMet
-
 ?
2.1.1.216 2 S-adenosyl-L-methionine + guanine26 in tRNALeu(UAG)
-
 Thermoplasma acidophilum 2 S-adenosyl-L-homocysteine + N2-dimethylguanine26 in tRNALeu(UAG)
-
 ?
2.1.1.216 4 S-adenosyl-L-methionine + guanine26 in initiator tRNAMet m2G26 and m22G26 are formed by Trm1 Thermoplasma acidophilum 4 S-adenosyl-L-homocysteine + N2-dimethylguanine26 in initiator tRNAMet
-
 ?
2.1.1.216 4 S-adenosyl-L-methionine + guanine26 in prolongator tRNAMet m2G26 and m22G26 are formed by Trm1 Thermoplasma acidophilum 4 S-adenosyl-L-homocysteine + N2-dimethylguanine26 in prolongator tRNAMet
-
 ?
2.1.1.216 4 S-adenosyl-L-methionine + guanine26 in tRNA
-
 Thermoplasma acidophilum 4 S-adenosyl-L-homocysteine + N2-dimethylguanine26 in tRNA
-
 ?
2.1.1.216 4 S-adenosyl-L-methionine + guanine26 in tRNA G modification at position 26 is a mixture of m2G and m22G generated by Trm1 Thermoplasma acidophilum 4 S-adenosyl-L-homocysteine + N2-dimethylguanine26 in tRNA
-
 ?
2.1.1.216 additional information the enzyme Trm1 is single site-specific Thermoplasma acidophilum ?
-
 ?
2.1.1.216 S-adenosyl-L-methionine + guanine26 in elongator tRNAMet
-
 Thermoplasma acidophilum S-adenosyl-L-homocysteine + N2-methylguanine26 in elongator tRNAMet
-
 ?
2.1.1.216 S-adenosyl-L-methionine + guanine26 in initiator tRNAMet
-
 Thermoplasma acidophilum S-adenosyl-L-homocysteine + N2-methylguanine26 in initiator tRNAMet
-
 ?
2.1.1.228 S-adenosyl-L-methionine + guanine37 in elongator tRNA
-
 Thermoplasma acidophilum S-adenosyl-L-homocysteine + N1-methylguanine37 in elongator tRNA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.206 Ta0931 locus name Thermoplasma acidophilum
2.1.1.206 Trm56
-
 Thermoplasma acidophilum
2.1.1.216 Ta0997 locus name Thermoplasma acidophilum
2.1.1.216 Trm1
-
 Thermoplasma acidophilum
2.1.1.216 tRNA (guanine(26)-N(2))-dimethyltransferase
-
 Thermoplasma acidophilum
2.1.1.228 Ta0997 locus name Thermoplasma acidophilum
2.1.1.228 Trm1
-
 Thermoplasma acidophilum

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.1.1.206 50
-
 assay at Thermoplasma acidophilum
2.1.1.216 50
-
 assay at Thermoplasma acidophilum
2.1.1.228 50
-
 assay at Thermoplasma acidophilum

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.1.206 7.6
-
 assay at Thermoplasma acidophilum
2.1.1.216 7.6
-
 assay at Thermoplasma acidophilum
2.1.1.228 7.6
-
 assay at Thermoplasma acidophilum

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.1.216 S-adenosyl-L-methionine
-
 Thermoplasma acidophilum

General Information

EC Number General Information Comment Organism
2.1.1.216 physiological function initiator tRNAMet from Thermoplasma acidophilum contains the m22G26 modification in addition to m2G26, the TrmI activity is responsible for these modifications Thermoplasma acidophilum