Any feedback?
Literature summary extracted from
- Two novel functions of hyaluronidase from Streptococcus agalactiae are enhanced intracellular survival and inhibition of proinflammatory cytokine expression (2014), Infect. Immun., 82, 2615-2625.
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.2.1.35 | extracellular | - |
Streptococcus agalactiae | - |
- |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.2.1.35 | hyaluronan + 2 H2O | Streptococcus agalactiae | - |
N-acetyl-beta-D-glucosamine + D-glucuronate + ? | - |
? |  |
| 3.2.1.35 | hyaluronan + 2 H2O | Streptococcus agalactiae GD201008-001 | - |
N-acetyl-beta-D-glucosamine + D-glucuronate + ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.2.1.35 | Streptococcus agalactiae | - |
- |
- |
| 3.2.1.35 | Streptococcus agalactiae GD201008-001 | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.2.1.35 | hyaluronan + 2 H2O | - |
Streptococcus agalactiae | N-acetyl-beta-D-glucosamine + D-glucuronate + ? | - |
? | |
| 3.2.1.35 | hyaluronan + 2 H2O | - |
Streptococcus agalactiae GD201008-001 | N-acetyl-beta-D-glucosamine + D-glucuronate + ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.2.1.35 | hyaluronidase | - |
Streptococcus agalactiae |
| 3.2.1.35 | HYL | - |
Streptococcus agalactiae |
| 3.2.1.35 | hylB | - |
Streptococcus agalactiae |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.2.1.35 | malfunction | enzyme deficiency reduces survival in macrophages compared to the wild type and stimulates a significantly higher release of proinflammatory cytokines, such as interleukin (IL)-1beta, IL-6, and tumor necrosis factor alpha than the wild type in macrophages as well as in mice | Streptococcus agalactiae |
| 3.2.1.35 | physiological function | hyaluronidase has a strong influence on the intracellular survival of Streptococcus agalactiae and proinflammatory cytokine expression, suggesting that it plays a key role in pathogenicity | Streptococcus agalactiae |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
