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Literature summary extracted from

  • Cao, Z.; Mulvihill, M.M.; Mukhopadhyay, P.; Xu, H.; Erdelyi, K.; Hao, E.; Holovac, E.; Hasko, G.; Cravatt, B.F.; Nomura, D.K.; Pacher, P.
    Monoacylglycerol lipase controls endocannabinoid and eicosanoid signaling and hepatic injury in mice (2013), Gastroenterology, 144, 808-817.e15.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.23 JZL184 selective inhibitor Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.23 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.23 hepatocyte
-
 Mus musculus
-
3.1.1.23 liver
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.23 2-arachidonoylglycerol + H2O
-
 Mus musculus glycerol + arachidonic acid
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.23 MAGL
-
 Mus musculus
3.1.1.23 monoacylglycerol lipase
-
 Mus musculus

General Information

EC Number General Information Comment Organism
3.1.1.23 malfunction enzyme inactivation attenuates hepatic ischemia/reperfusion-induced tissue injury, inflammation and oxidative stress Mus musculus
3.1.1.23 physiological function monoacylglycerol lipase promotes hepatic injury via endocannabinoid and eicosanoid signaling Mus musculus