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Literature summary extracted from

  • Scandroglio, F.; Tortora, V.; Radi, R.; Castro, L.
    Metabolic control analysis of mitochondrial aconitase: influence over respiration and mitochondrial superoxide and hydrogen peroxide production (2014), Free Radic. Res., 48, 684-693.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.3 Fluorocitrate
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.2.1.3 mitochondrion
-
 Rattus norvegicus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.3 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.2.1.3 brain aconitase-specific activity increases by 42% at 2% O2 compared to 21% O2 Rattus norvegicus
-
4.2.1.3 heart aconitase-specific activity increases by 12% at 2% O2 compared to 21% O2 Rattus norvegicus
-
4.2.1.3 kidney
-
 Rattus norvegicus
-
4.2.1.3 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.3 cis-aconitate + H2O
-
 Rattus norvegicus isocitrate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.2.1.3 aconitase
-
 Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.2.1.3 7.4
-
 assay at Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
4.2.1.3 0.007
-
 pH 7.4, temperature not specified in the publication, tissue: brain Rattus norvegicus Fluorocitrate
4.2.1.3 0.012
-
 pH 7.4, temperature not specified in the publication, tissue: heart Rattus norvegicus Fluorocitrate
4.2.1.3 0.024
-
 pH 7.4, temperature not specified in the publication, tissue: kidney Rattus norvegicus Fluorocitrate
4.2.1.3 0.024
-
 pH 7.4, temperature not specified in the publication, tissue: liver Rattus norvegicus Fluorocitrate