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Literature summary extracted from

  • Endo, T.; Yanagawa, Y.; Komatsu, Y.
    Substance P activates Ca2+-permeable nonselective cation channels through a phosphatidylcholine-specific phospholipase C signaling pathway in nNOS-expressing GABAergic neurons in visual cortex (2014), Cereb. Cortex, 26, 669-682.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.3 tricyclodecan-9-yl-xanthogenate i.e. D609, a specific inhibitor, significantly suppresses the (S)-3-methyl-2-phenyl-N-(1-phenylpropyl)-4-quinolinecarboxamide-induced current in type I nNOS neurons Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.3 phosphatidylcholine + H2O Mus musculus
-
 1,2-sn-diacylglycerol + phosphocholine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.3 Mus musculus
-
 glutamate decarboxylase 67-green fluorescent protein, GAD67-GFP, knock-in mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.3 neuron GFP-positive visual cortical neurons, type I nNOS neurons Mus musculus
-
3.1.4.3 visual cortex
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.3 phosphatidylcholine + H2O
-
 Mus musculus 1,2-sn-diacylglycerol + phosphocholine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.3 PC-PLC
-
 Mus musculus
3.1.4.3 phosphatidylcholine-specific phospholipase C
-
 Mus musculus

General Information

EC Number General Information Comment Organism
3.1.4.3 metabolism (S)-3-methyl-2-phenyl-N-(1-phenylpropyl)-4-quinolinecarboxamide activates TRP-like ion channels through an phosphatidylcholine-specific phospholipase C-dependent signaling pathway, mechanism, overview Mus musculus
3.1.4.3 physiological function the enzyme is involved in the regulation of Ca2+-permeable nonselective cation channels. (S)-3-methyl-2-phenyl-N-(1-phenylpropyl)-4-quinolinecarboxamide-induced current is mediated by the enzyme in neuronal nitric oxide synthase-expressing, GFP-responsive GABAergic neurons of the visual neocortex. (S)-3-methyl-2-phenyl-N-(1-phenylpropyl)-4-quinolinecarboxamide-induced current is mediated by G proteins and suppressed by D609, an inhibitor of phosphatidylcholine-specific phospholipase C, but not by inhibitors of phosphatidylinositol-specific phospholipase C, EC 3.1.4.11, adenylate cyclase or Src tyrosine kinases Mus musculus