EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
3.1.1.34 | angiopoietin-like protein 4 | major physiological regulator of enzyme activity under conditions of fasting and exercise | Mus musculus | |
3.1.1.34 | apolipoprotein A5 | - |
Mus musculus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.1.1.34 | ANGPTL4 | conventional, non-competitive inhibitor | Mus musculus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.1.34 | triacylglycerol + H2O | Mus musculus | - |
diacylglycerol + a carboxylate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.1.34 | Mus musculus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.1.1.34 | brain | - |
Mus musculus | - |
3.1.1.34 | brown adipose tissue | - |
Mus musculus | - |
3.1.1.34 | heart | - |
Mus musculus | - |
3.1.1.34 | kidney | - |
Mus musculus | - |
3.1.1.34 | liver | - |
Mus musculus | - |
3.1.1.34 | lung | - |
Mus musculus | - |
3.1.1.34 | macrophage | - |
Mus musculus | - |
3.1.1.34 | mammary gland | - |
Mus musculus | - |
3.1.1.34 | skeletal muscle | - |
Mus musculus | - |
3.1.1.34 | white adipose tissue | - |
Mus musculus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.1.34 | triacylglycerol + H2O | - |
Mus musculus | diacylglycerol + a carboxylate | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
3.1.1.34 | dimer | - |
Mus musculus |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.1.1.34 | LPL | - |
Mus musculus |
EC Number | Organism | Comment | Expression |
---|---|---|---|
3.1.1.34 | Mus musculus | stress and catecholamines reduce adipose enzyme activity. Tissue necrosis factpor alpha represses enzyme activity by downregulating transcription | down |
3.1.1.34 | Mus musculus | insulin, dexamethasone and cortisol increase mRNA and activity in adipose organs. Cold markedly stimulates enzyme activity in brown adipose tissue | up |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.1.1.34 | physiological function | the enzyme is rate limiting for plasma triglyceride clearance and tissue uptake of fatty acids | Mus musculus |