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Literature summary extracted from

  • Song, D.D.; Chen, Y.; Li, Z.Y.; Guan, Y.F.; Zou, D.J.; Miao, C.Y.
    Protein tyrosine phosphatase 1B inhibits adipocyte differentiation and mediates TNFalpha action in obesity (2013), Biochim. Biophys. Acta, 1831, 1368-1376.
    View publication on PubMed

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.3.48 50000
-
 x * 50000, SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.48 [a protein]-tyrosine phosphate + H2O Mus musculus
-
 [a protein]-tyrosine + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.48 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.48 3T3-L1 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.48 [a protein]-tyrosine phosphate + H2O
-
 Mus musculus [a protein]-tyrosine + phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.3.48 ? x * 50000, SDS-PAGE Mus musculus

Synonyms

EC Number Synonyms Comment Organism
3.1.3.48 protein tyrosine phosphatase 1B
-
 Mus musculus
3.1.3.48 PTP1B
-
 Mus musculus

Expression

EC Number Organism Comment Expression
3.1.3.48 Mus musculus PTP1B expression decreases progressively with adipocyte maturation down

General Information

EC Number General Information Comment Organism
3.1.3.48 malfunction PTP1B knockdown accelerates adipocyte differentiation Mus musculus
3.1.3.48 physiological function protein tyrosine phosphatase 1B is a negative regulator of systemic glucose and insulin homeostasis and inhibits adipocyte differentiation and mediates TNFalpha action in obesity Mus musculus