BRENDA - Enzyme Database

Dissection of porphyrin-induced conformational dynamics in the heme biosynthesis enzyme ferrochelatase

Asuru, A.P.; An, M.; Busenlehner, L.S.; Biochemistry 51, 7116-7127 (2012)

Data extracted from this reference:

Cloned(Commentary)
EC Number
Commentary
Organism
4.99.1.1
expressed in Escherichia coli HB101 cells
Homo sapiens
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
4.99.1.1
mitochondrial inner membrane
-
Homo sapiens
5743
-
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
4.99.1.1
Fe2+
contains 1.8 mol iron per mol ferrochelatase
Homo sapiens
Molecular Weight [Da]
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
4.99.1.1
84000
-
gel filtration
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
4.99.1.1
protoporphyrin IX + Fe2+
Homo sapiens
-
protoheme IX + H+
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
4.99.1.1
Homo sapiens
-
-
-
Purification (Commentary)
EC Number
Commentary
Organism
4.99.1.1
-
Homo sapiens
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.99.1.1
mesoporphyrin IX + Fe2+
-
729221
Homo sapiens
?
-
-
-
?
4.99.1.1
protoporphyrin IX + Fe2+
-
729221
Homo sapiens
protoheme IX + H+
-
-
-
?
Subunits
EC Number
Subunits
Commentary
Organism
4.99.1.1
homodimer
-
Homo sapiens
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
4.99.1.1
[2Fe-2S]-center
-
Homo sapiens
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
4.99.1.1
expressed in Escherichia coli HB101 cells
Homo sapiens
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
4.99.1.1
[2Fe-2S]-center
-
Homo sapiens
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
4.99.1.1
mitochondrial inner membrane
-
Homo sapiens
5743
-
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
4.99.1.1
Fe2+
contains 1.8 mol iron per mol ferrochelatase
Homo sapiens
Molecular Weight [Da] (protein specific)
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
4.99.1.1
84000
-
gel filtration
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
4.99.1.1
protoporphyrin IX + Fe2+
Homo sapiens
-
protoheme IX + H+
-
-
?
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
4.99.1.1
-
Homo sapiens
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.99.1.1
mesoporphyrin IX + Fe2+
-
729221
Homo sapiens
?
-
-
-
?
4.99.1.1
protoporphyrin IX + Fe2+
-
729221
Homo sapiens
protoheme IX + H+
-
-
-
?
Subunits (protein specific)
EC Number
Subunits
Commentary
Organism
4.99.1.1
homodimer
-
Homo sapiens
General Information
EC Number
General Information
Commentary
Organism
4.99.1.1
metabolism
the enzyme catalyzes the insertion ferrous iron into protoporphyrin IX as the last step in heme biosynthesis
Homo sapiens
General Information (protein specific)
EC Number
General Information
Commentary
Organism
4.99.1.1
metabolism
the enzyme catalyzes the insertion ferrous iron into protoporphyrin IX as the last step in heme biosynthesis
Homo sapiens