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Literature summary extracted from

  • Heneberg, P.
    Reactive nitrogen species and hydrogen sulfide as regulators of protein tyrosine phosphatase activity (2014), Antioxid. Redox Signal., 20, 2191-2209.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
3.1.3.48 C11A inactive Mycobacterium tuberculosis
3.1.3.48 C16A the mutant retains the activity similar to the wild type enzyme Mycobacterium tuberculosis
3.1.3.48 C53A the mutant is insensitive to S-nitrosoglutathione treatment Mycobacterium tuberculosis

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.48 S-nitrosoglutathione S-nitrosoglutathione treatment decreases the catalytic activity parameters of PtpA by half Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.48 [a protein]-tyrosine phosphate + H2O Mycobacterium tuberculosis
-
 [a protein]-tyrosine + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.48 Mycobacterium tuberculosis
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.3.48 S-nitrosylation
-
 Mycobacterium tuberculosis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.48 [a protein]-tyrosine phosphate + H2O
-
 Mycobacterium tuberculosis [a protein]-tyrosine + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.48 LMW-PTP
-
 Mycobacterium tuberculosis
3.1.3.48 protein tyrosine phosphatase
-
 Mycobacterium tuberculosis
3.1.3.48 PtpA
-
 Mycobacterium tuberculosis