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Literature summary extracted from

  • Roessler, C.; Nowak, T.; Pannek, M.; Gertz, M.; Nguyen, G.T.; Scharfe, M.; Born, I.; Sippl, W.; Steegborn, C.; Schutkowski, M.
    Chemical probing of the human sirtuin 5 active site reveals its substrate acyl specificity and peptide-based inhibitors (2014), Angew. Chem. Int. Ed. Engl., 53, 10728-10732.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.B43 benzoyl-GVL(N6-(3-acetylthiosuccinyl))KEYGV-amide
-
 Homo sapiens
2.3.1.B43 benzoyl-GVL(N6-(3-butylsuccinyl))KEYGV-amide
-
 Homo sapiens
2.3.1.B43 benzoyl-GVL(N6-(3-methyl-3-phenyl)succinyl)KEYGV-amide
-
 Homo sapiens
2.3.1.B43 benzoyl-GVL(N6-(3-phenyl)succinyl)KEYGV-amide
-
 Homo sapiens
2.3.1.B43 benzoyl-GVL(N6-(N-benzyloxycarbonyl-L-aspartyl))KEYGV-amide
-
 Homo sapiens
2.3.1.B43 benzoyl-GVL(N6-(N-phthaloyl-DL-gamma-glutamyl))KEYGV-amide
-
 Homo sapiens
2.3.1.B43 benzoyl-GVL(N6-(N2-Fmoc-beta-L-aspartyl))KEYGV-amide
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.B43 0.0038
-
 benzoyl-GVL(N6-succinyl)KEYGV-amide pH 7.8, 37°C Homo sapiens
2.3.1.B43 0.0041
-
 benzoyl-GVL(N6-glutaryl)KEYGV-amide pH 7.8, 37°C Homo sapiens
2.3.1.B43 0.0051
-
 benzoyl-GVL(N6-malonyl)KEYGV-amide pH 7.8, 37°C Homo sapiens
2.3.1.B43 0.0065
-
 benzoyl-GVL(N6-adipoyl)KEYGV-amide pH 7.8, 37°C Homo sapiens
2.3.1.B43 0.0243
-
 benzoyl-GVL(N6-acetyl)KEYGV-amide pH 7.8, 37°C Homo sapiens
2.3.1.B43 0.0805
-
 benzoyl-GVL(N6-pimeloyl)KEYGV-amide pH 7.8, 37°C Homo sapiens
2.3.1.B43 0.409
-
 benzoyl-GVL(N6-suberoyl)KEYGV-amide pH 7.8, 37°C Homo sapiens
2.3.1.B43 0.416
-
 benzoyl-GVL(N6-oxalyl)KEYGV-amide pH 7.8, 37°C Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.B43 Homo sapiens Q9NXA8
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.B43 NAD+ + benzoyl-GVL(N6-acetyl)KEYGV-amide
-
 Homo sapiens nicotinamide + benzoyl-GVLKEYGV-amide + 2'-O-acetyl-ADP-ribose
-
 ?
2.3.1.B43 NAD+ + benzoyl-GVL(N6-adipoyl)KEYGV-amide
-
 Homo sapiens nicotinamide + benzoyl-GVLKEYGV-amide + 2'-O-adipoyl-ADP-ribose
-
 ?
2.3.1.B43 NAD+ + benzoyl-GVL(N6-glutaryl)KEYGV-amide
-
 Homo sapiens nicotinamide + benzoyl-GVLKEYGV-amide + 2'-O-glutaryl-ADP-ribose
-
 ?
2.3.1.B43 NAD+ + benzoyl-GVL(N6-malonyl)KEYGV-amide
-
 Homo sapiens nicotinamide + benzoyl-GVLKEYGV-amide + 2'-O-malonyl-ADP-ribose
-
 ?
2.3.1.B43 NAD+ + benzoyl-GVL(N6-oxalyl)KEYGV-amide
-
 Homo sapiens nicotinamide + benzoyl-GVLKEYGV-amide + 2'-O-oxalyl-ADP-ribose
-
 ?
2.3.1.B43 NAD+ + benzoyl-GVL(N6-pimeloyl)KEYGV-amide
-
 Homo sapiens nicotinamide + benzoyl-GVLKEYGV-amide + 2'-O-pimeloyl-ADP-ribose
-
 ?
2.3.1.B43 NAD+ + benzoyl-GVL(N6-suberoyl)KEYGV-amide
-
 Homo sapiens nicotinamide + benzoyl-GVLKEYGV-amide + 2'-O-suberoyl-ADP-ribose
-
 ?
2.3.1.B43 NAD+ + benzoyl-GVL(N6-succinyl)KEYGV-amide
-
 Homo sapiens nicotinamide + benzoyl-GVLKEYGV-amide + 2'-O-succinyl-ADP-ribose
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.B43 sirtuin 5
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.B43 37
-
 assay at Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.3.1.B43 0.00028
-
 benzoyl-GVL(N6-pimeloyl)KEYGV-amide pH 7.8, 37°C Homo sapiens
2.3.1.B43 0.00039
-
 benzoyl-GVL(N6-acetyl)KEYGV-amide pH 7.8, 37°C Homo sapiens
2.3.1.B43 0.00053
-
 benzoyl-GVL(N6-suberoyl)KEYGV-amide pH 7.8, 37°C Homo sapiens
2.3.1.B43 0.0016
-
 benzoyl-GVL(N6-oxalyl)KEYGV-amide pH 7.8, 37°C Homo sapiens
2.3.1.B43 0.01
-
 benzoyl-GVL(N6-adipoyl)KEYGV-amide pH 7.8, 37°C Homo sapiens
2.3.1.B43 0.019
-
 benzoyl-GVL(N6-malonyl)KEYGV-amide pH 7.8, 37°C Homo sapiens
2.3.1.B43 0.053
-
 benzoyl-GVL(N6-succinyl)KEYGV-amide pH 7.8, 37°C Homo sapiens
2.3.1.B43 0.077
-
 benzoyl-GVL(N6-glutaryl)KEYGV-amide pH 7.8, 37°C Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.B43 7.8
-
 assay at Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.1.B43 0.0043
-
 benzoyl-GVL(N6-(3-methyl-3-phenyl)succinyl)KEYGV-amide pH 7.8, 37°C Homo sapiens
2.3.1.B43 0.0106
-
 benzoyl-GVL(N6-(3-acetylthiosuccinyl))KEYGV-amide pH 7.8, 37°C Homo sapiens
2.3.1.B43 0.0172
-
 benzoyl-GVL(N6-(3-butylsuccinyl))KEYGV-amide pH 7.8, 37°C Homo sapiens
2.3.1.B43 0.0249
-
 benzoyl-GVL(N6-(N-phthaloyl-DL-gamma-glutamyl))KEYGV-amide pH 7.8, 37°C Homo sapiens
2.3.1.B43 0.0381
-
 benzoyl-GVL(N6-(N-benzyloxycarbonyl-L-aspartyl))KEYGV-amide pH 7.8, 37°C Homo sapiens
2.3.1.B43 0.046
-
 benzoyl-GVL(N6-(N2-Fmoc-beta-L-aspartyl))KEYGV-amide pH 7.8, 37°C Homo sapiens
2.3.1.B43 0.1
-
 benzoyl-GVL(N6-(3-phenyl)succinyl)KEYGV-amide pH 7.8, 37°C Homo sapiens

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
2.3.1.B43 0.001
-
 benzoyl-GVL(N6-suberoyl)KEYGV-amide pH 7.8, 37°C Homo sapiens
2.3.1.B43 0.004
-
 benzoyl-GVL(N6-oxalyl)KEYGV-amide pH 7.8, 37°C Homo sapiens
2.3.1.B43 0.004
-
 benzoyl-GVL(N6-pimeloyl)KEYGV-amide pH 7.8, 37°C Homo sapiens
2.3.1.B43 0.016
-
 benzoyl-GVL(N6-acetyl)KEYGV-amide pH 7.8, 37°C Homo sapiens
2.3.1.B43 1.54
-
 benzoyl-GVL(N6-adipoyl)KEYGV-amide pH 7.8, 37°C Homo sapiens
2.3.1.B43 3.76
-
 benzoyl-GVL(N6-malonyl)KEYGV-amide pH 7.8, 37°C Homo sapiens
2.3.1.B43 13.9
-
 benzoyl-GVL(N6-succinyl)KEYGV-amide pH 7.8, 37°C Homo sapiens
2.3.1.B43 18.7
-
 benzoyl-GVL(N6-glutaryl)KEYGV-amide pH 7.8, 37°C Homo sapiens