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Literature summary extracted from

  • Maioli, S.; Bavner, A.; Ali, Z.; Heverin, M.; Ismail, M.A.; Puerta, E.; Olin, M.; Saeed, A.; Shafaati, M.; Parini, P.; Cedazo-Minguez, A.; Bjoerkhem, I.
    Is it possible to improve memory function by upregulation of the cholesterol 24S-hydroxylase (CYP46A1) in the brain? (2013), PLoS ONE, 8, e68534.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.14.25 expressed in Mus musculus Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.25 cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2 Homo sapiens
-
 (24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.25 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.25 brain
-
 Homo sapiens
-
1.14.14.25 eye
-
 Homo sapiens
-
1.14.14.25 hippocampus
-
 Homo sapiens
-
1.14.14.25 testis
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.25 cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2
-
 Homo sapiens (24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.25 24S-hydroxylase
-
 Homo sapiens
1.14.14.25 CYP46A1
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.25 NADPH
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.14.14.25 physiological function CYP46A1 overexpression enhances spatial memory retention in aged female mice Homo sapiens