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Literature summary extracted from
- Leishmania major protein disulfide isomerase as a drug target: enzymatic and functional characterization (2012), Parasitol. Res., 110, 1911-1917.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.3.4.1 | bacitracin | full inhibition of reductase activity at 0.2 mM | Leishmania major |  |
| 5.3.4.1 | additional information | ribostamycin has very slight inhibitory effect on protein disulfide isomerase chaperone activity and no effect on both reductase and isomerase activities | Leishmania major |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.3.4.1 | Insulin-(SS) + GSH | Leishmania major | - |
Insulin-(SH)2 + GSSG | - |
? | |
| 5.3.4.1 | Insulin-(SS) + GSH | Leishmania major MHOM/TN/94/GLC94 | - |
Insulin-(SH)2 + GSSG | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.3.4.1 | Leishmania major | - |
- |
- |
| 5.3.4.1 | Leishmania major MHOM/TN/94/GLC94 | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.3.4.1 | Insulin-(SS) + GSH | - |
Leishmania major | Insulin-(SH)2 + GSSG | - |
? | |
| 5.3.4.1 | Insulin-(SS) + GSH | - |
Leishmania major MHOM/TN/94/GLC94 | Insulin-(SH)2 + GSSG | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 5.3.4.1 | PDI | - |
Leishmania major |
| 5.3.4.1 | protein disulfide isomerase | - |
Leishmania major |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 5.3.4.1 | 0.0811 | - |
pH and temperature not specified in the publication | Leishmania major | bacitracin | |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 5.3.4.1 | physiological function | the enzyme plays a key role in assisting Leishmania protein folding via its capacity to catalyze formation, breakage, and rearrangement of disulfide bonds in nascent polypeptides. The enzyme displays a chaperone-like activity | Leishmania major |
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Release 2023.1 (January 2023)
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