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Literature summary extracted from

  • Stuecker, T.; Tucker, A.; Escalante-Semerena, J.
    PanM, an acetyl-coenzyme a sensor required for maturation of L-aspartate decarboxylase (PanD) (2012), mBio, 3, e00158-12.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.1.1.11 additional information no activation with the CoA-binding-deficient PanMG76L variant Salmonella enterica
4.1.1.11 PanM Salmonella enterica PanM, formerly YhhK, a Gcn5-like N-acetyltransferase, is necessary for pro-PanD maturation, both in vitro and in vivo. PanM-dependent pro-PanD maturation does not involve an acetyl transfer event. CoA binding to PanM is needed for in vivo activity, disruption of CoA binding prevents PanM from interacting with PanD. PanM lacks acetyltransferase activity but functions instead as an acetyl-coenzyme A (CoA) sensor, overview Salmonella enterica

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.11 L-aspartate Salmonella enterica
-
 beta-alanine + CO2
-
 ?
4.1.1.11 L-aspartate Salmonella enterica DM10310
-
 beta-alanine + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.11 Salmonella enterica
-
 serovar Typhimurium LT2, gene panD
-
4.1.1.11 Salmonella enterica DM10310
-
 serovar Typhimurium LT2, gene panD
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
4.1.1.11 proteolytic modification PanD is a pyruvoyl enzyme that is synthesized by the cell as an inactive precursor, pro-PanD. Maturation of pro-PanD into PanD occurs via a self-cleavage event at residue Ser25, which forms the catalytic pyruvoyl moiety. Salmonella enterica PanM, a Gcn5-like N-acetyltransferase, is necessary for pro-PanD maturation, both in vitro and in vivo Salmonella enterica

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.11 L-aspartate
-
 Salmonella enterica beta-alanine + CO2
-
 ?
4.1.1.11 L-aspartate
-
 Salmonella enterica DM10310 beta-alanine + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.1.11 PanD
-
 Salmonella enterica