EC Number | Application | Comment | Organism |
---|---|---|---|
5.3.3.8 | medicine | enzyme is involved in controlling host metabolic reprogramming during hepatitis C virus infection. Hepatitis C virus growth and RNA replication in hepatoma cell lines stably expressing dodecenoyl coenzyme A delta isomerase-targeting short hairpin RNA (shRNA) are abrogated, indicating that dodecenoyl coenzyme A delta isomerase is required for productive infection. Pharmacologic inhibition of fatty acid oxidation also blocks hepatitis C virus replication. Production of infectious hepatitis C virus is restored by overexpression of an shRNA-resistant dodecenoyl coenzyme A delta isomerase allele | Homo sapiens |
EC Number | Cloned (Comment) | Organism |
---|---|---|
5.3.3.8 | expressed in Escherichia coli DH5alpha cells | Hepacivirus C |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
5.3.3.8 | mitochondrion | - |
Homo sapiens | 5739 | - |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
5.3.3.8 | Hepacivirus C | - |
- |
- |
5.3.3.8 | Homo sapiens | P42126 | - |
- |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
5.3.3.8 | DCI | - |
Hepacivirus C |
5.3.3.8 | dodecenoyl coenzyme A DELTA isomerase | - |
Hepacivirus C |
5.3.3.8 | dodecenoyl coenzyme A DELTA isomerase | - |
Homo sapiens |
5.3.3.8 | ECI1 | - |
Homo sapiens |
EC Number | General Information | Comment | Organism |
---|---|---|---|
5.3.3.8 | malfunction | enzyme knockdown of inhibits hepatitis C virus RNA replication in cultured hepatoma cells. Enzyme deficiency causes alterations in the cellular metabolome | Hepacivirus C |
5.3.3.8 | physiological function | the enzyme is required for hepatitis C virus replication and likely pathogenesis | Hepacivirus C |