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Literature summary extracted from
- Catalytic mechanism and product specificity of oxidosqualene-lanosterol cyclase: a QM/MM study (2012), J. Phys. Chem. B, 116, 13857-13862.
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 5.4.99.7 | H232S | site-directed mutagenesis, mutant energy profile compared to the wild-type enzyme | Homo sapiens |
| 5.4.99.7 | H232T | site-directed mutagenesis, mutant energy profile compared to the wild-type enzyme | Homo sapiens |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.4.99.7 | (3S)-2,3-epoxy-2,3-dihydrosqualene | Homo sapiens | - |
lanosterol | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.4.99.7 | Homo sapiens | - |
- |
- |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 5.4.99.7 | (3S)-2,3-epoxy-2,3-dihydrosqualene = lanosterol | catalytic mechanism involving His232 via intermediates parkeol and protosta-12,24-dien-3-beta-ol, quantum mechanics/molecular mechanics, overview | Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.4.99.7 | (3S)-2,3-epoxy-2,3-dihydrosqualene | - |
Homo sapiens | lanosterol | - |
? | |
| 5.4.99.7 | (3S)-2,3-epoxy-2,3-dihydrosqualene | reaction of wild-type enzyme, via intermediates parkeol and protosta-12,24-dien-3-beta-ol | Homo sapiens | lanosterol | - |
? | |
| 5.4.99.7 | (3S)-2,3-epoxy-2,3-dihydrosqualene | reaction of mutant H232S | Homo sapiens | parkeol | - |
? | |
| 5.4.99.7 | (3S)-2,3-epoxy-2,3-dihydrosqualene | reaction of mutant H232T | Homo sapiens | protosta-12,24-dien-3-beta-ol | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 5.4.99.7 | OSC | - |
Homo sapiens |
| 5.4.99.7 | Oxidosqualene-lanosterol cyclase | - |
Homo sapiens |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 5.4.99.7 | metabolism | oxidosqualene-lanosterol cyclase is a key enzyme in the biosynthesis of cholesterol | Homo sapiens |
| 5.4.99.7 | additional information | H232 mutant energy profiles compared to the wild-type enzyme, overview | Homo sapiens |
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