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Literature summary extracted from

  • Siam, A.; Brancale, A.; Simons, C.
    Comparative modeling of 25-hydroxycholesterol-7alpha-hydroxylase (CYP7B1): ligand binding and analysis of hereditary spastic paraplegia type 5 CYP7B1 mutations (2012), J. Mol. Model., 18, 441-453.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.14.29 3alpha-adiol
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.29 25-hydroxycholesterol + NADPH + H+ + O2 Homo sapiens
-
 ? + NADP+ + H2O
-
 ?
1.14.14.29 27-hydroxycholesterol + NADPH + H+ + O2 Homo sapiens
-
 3beta,7alpha-dihydroxy-5-cholestenoic acid + NADP+ + H2O
-
 ?
1.14.14.29 dehydroepiandrosterone + NADPH + H+ + o2 Homo sapiens
-
 7alpha-hydroxy-dehydroepiandrosterone + NADP+ + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.29 Homo sapiens O75881
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.29 25-hydroxycholesterol + NADPH + H+ + O2
-
 Homo sapiens ? + NADP+ + H2O
-
 ?
1.14.14.29 27-hydroxycholesterol + NADPH + H+ + O2
-
 Homo sapiens 3beta,7alpha-dihydroxy-5-cholestenoic acid + NADP+ + H2O
-
 ?
1.14.14.29 dehydroepiandrosterone + NADPH + H+ + o2
-
 Homo sapiens 7alpha-hydroxy-dehydroepiandrosterone + NADP+ + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.29 25-hydroxycholesterol-7alpha-hydroxylase
-
 Homo sapiens
1.14.14.29 CYP7B1
-
 Homo sapiens
1.14.14.29 oxysterol-7alpha-hydroxylase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.29 NADPH
-
 Homo sapiens