BRENDA - Enzyme Database

Isocitrate dehydrogenase from the hyperthermophile Aeropyrum pernix: X-ray structure analysis of a ternary enzyme-substrate complex and thermal stability

Karlström, M.; Stokke, R.; Steen, I.H.; Birkeland, N.K.; Ladenstein, R.; J. Mol. Biol. 345, 559-577 (2005)

Data extracted from this reference:

Crystallization (Commentary)
EC Number
Crystallization
Organism
1.1.1.42
crystal structures of a native enzyme at 2.2 A, a pseudo-native enzyme at 2.1 A, and of the enzyme in complex with NADP+, Ca2+ and D-isocitrate at 2.3 A
Aeropyrum pernix
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.1.1.42
Aeropyrum pernix
Q9YE81
-
-
1.1.1.42
Aeropyrum pernix DSM 11879
Q9YE81
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.42
isocitrate + NADP+
-
728133
Aeropyrum pernix
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
1.1.1.42
isocitrate + NADP+
-
728133
Aeropyrum pernix DSM 11879
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
Subunits
EC Number
Subunits
Commentary
Organism
1.1.1.42
homodimer
-
Aeropyrum pernix
Crystallization (Commentary) (protein specific)
EC Number
Crystallization
Organism
1.1.1.42
crystal structures of a native enzyme at 2.2 A, a pseudo-native enzyme at 2.1 A, and of the enzyme in complex with NADP+, Ca2+ and D-isocitrate at 2.3 A
Aeropyrum pernix
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.42
isocitrate + NADP+
-
728133
Aeropyrum pernix
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
1.1.1.42
isocitrate + NADP+
-
728133
Aeropyrum pernix DSM 11879
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
Subunits (protein specific)
EC Number
Subunits
Commentary
Organism
1.1.1.42
homodimer
-
Aeropyrum pernix