EC Number | Cloned (Comment) | Organism |
---|---|---|
1.13.99.1 | expressed in Escherichia coli | Mus musculus |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
1.13.99.1 | S24A/S205A/S218A/T29A/T69A | mutated putative PKA phosphorylation sites: mutant is also phosphorylated but to a minor degree | Mus musculus |
1.13.99.1 | S24A/S205A/S218A/T29A/T69A/S64A/T40A/T49A/T69A/T253A | mutated putative PKA and PKC phosphorylation sites: mutant is also phosphorylated but to a minor degree | Mus musculus |
1.13.99.1 | S64A/T40A/T49A/T69A/T253A | mutated putative PKC phosphorylation sites: mutant is also phosphorylated but to a minor degree | Mus musculus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.13.99.1 | Mus musculus | - |
- |
- |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
1.13.99.1 | phosphoprotein | mutants with substituted phosphorylation sites have a minimal increase in activity. Treatment of cells with PKC, PKA, and PDK1 kinase activators increased activity, whereas inhibitors reduced it. Protein kinases A, C, and PDK1 are capable of phosphorylating mouse in both prokaryotic and eukaryotic systems. Using deletion constructs it is shown that the N-terminus contains the critical phosphorylation sites that are highly relevant to the functionality of the protein | Mus musculus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.13.99.1 | kidney | - |
Mus musculus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.13.99.1 | myo-inositol + O2 | - |
Mus musculus | D-glucuronic acid + H2O | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.13.99.1 | Myo-inositol oxygenase | - |
Mus musculus |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.13.99.1 | 30 | - |
assay at | Mus musculus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.13.99.1 | 8 | - |
assay at | Mus musculus |
EC Number | Organism | Comment | Expression |
---|---|---|---|
1.13.99.1 | Mus musculus | antioxidants N-acetylcysteine, beta-naphthoflavone, and tertiary butyl hydroquinone reduces MIOX expression | down |
1.13.99.1 | Mus musculus | high glucose levels, exposure of cells to oxidants H2O2 and methylglyoxal up-regulates MIOX expression | up |