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Literature summary extracted from

  • Porat, I.; Waters, B.W.; Teng, Q.; Whitman, W.B.
    Two biosynthetic pathways for aromatic amino acids in the archaeon Methanococcus maripaludis (2004), J. Bacteriol., 186, 4940-4950.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.2.1.51 tyrosine
-
 Methanococcus maripaludis

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.51 L-phenylalanine
-
 Methanococcus maripaludis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.2.1.51 1.2
-
 prephenate pH and temperature not specified in the publication Methanococcus maripaludis

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.2.1.51 KCl
-
 Methanococcus maripaludis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.1.51 prephenate Methanococcus maripaludis first enzyme in the phenylalanine biosynthesis branch of the biosynthetic pathway for aromatic amino acids phenylpyruvate + H2O + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.7.8 Methanococcus maripaludis Q6LZB6 and Q6LZB5 Q6LZB6: subunit alpha 2, Q6LZB5: subunit beta 2
-
1.2.7.8 Methanococcus maripaludis Q6M0F5 and Q6M0F6 Q6M0F5: subunit alpha 1, Q6M0F6: subunit beta 1
-
4.2.1.51 Methanococcus maripaludis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.51 prephenate
-
 Methanococcus maripaludis phenylpyruvate + H2O + CO2
-
 ?
4.2.1.51 prephenate first enzyme in the phenylalanine biosynthesis branch of the biosynthetic pathway for aromatic amino acids Methanococcus maripaludis phenylpyruvate + H2O + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.7.8 IOR Methanococcus maripaludis has two IOR homologs Methanococcus maripaludis
4.2.1.51 PDT
-
 Methanococcus maripaludis

Expression

EC Number Organism Comment Expression
4.2.1.51 Methanococcus maripaludis the presence of aryl acids does not have a large affect on the expression of the enzyme additional information

General Information

EC Number General Information Comment Organism
1.2.7.8 malfunction Methanococcus maripaludis has two IOR homologs. A deletion mutant for one of these homologs contains 76, 74, and 42% lower activity for phenylpyruvate, p-hydroxyphenylpyruvate, and indolepyruvate oxidation, respectively, than the wild type. Growth of this mutant in minimal medium is inhibited by the aryl acids, but the aromatic amino aciuds partially restore growth Methanococcus maripaludis