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Literature summary extracted from
- Alkylglycerol monooxygenase (2013), IUBMB Life, 65, 366-372.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.14.16.5 | expressed in Chinese hamster ovary cells | Rattus norvegicus |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.14.16.5 | microsome | - |
Rattus norvegicus | - |
- |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.16.5 | Iron | the enzyme uses a di-iron centre for catalysis | Rattus norvegicus |  |
| 1.14.16.5 | Iron | the enzyme uses a di-iron centre for catalysis | Caenorhabditis elegans | |
| 1.14.16.5 | Iron | the enzyme uses a di-iron centre for catalysis | Danio rerio | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.14.16.5 | 40500 | - |
x * 40500, SDS-PAGE | Rattus norvegicus |
| 1.14.16.5 | 40500 | - |
x * 40500, SDS-PAGE | Caenorhabditis elegans |
| 1.14.16.5 | 40500 | - |
x * 40500, SDS-PAGE | Danio rerio |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.16.5 | 1-O-alkyl-sn-glycerol 3-phosphate + tetrahydrobiopterin + O2 | Caenorhabditis elegans | - |
1-O-(1-hydroxyalkyl)-sn-glycerol 3-phosphate + 6,7-[8]-dihydrobiopterin + H2O | - |
? | |
| 1.14.16.5 | 1-O-alkyl-sn-glycerol 3-phosphate + tetrahydrobiopterin + O2 | Danio rerio | - |
1-O-(1-hydroxyalkyl)-sn-glycerol 3-phosphate + 6,7-[8]-dihydrobiopterin + H2O | - |
? | |
| 1.14.16.5 | lyso-alkyl-glycerol phospholipid + tetrahydrobiopterin + O2 | Rattus norvegicus | - |
1-O-(1-hydroxyalkyl)-sn-glycerol + 6,7-[8]-dihydrobiopterin + H2O | - |
? | |
| 1.14.16.5 | lyso-platelet activating factor + tetrahydrobiopterin + O2 | Rattus norvegicus | good substrate | ? | - |
? | |
| 1.14.16.5 | lyso-platelet activating factor + tetrahydrobiopterin + O2 | Caenorhabditis elegans | good substrate | ? | - |
? | |
| 1.14.16.5 | lyso-platelet activating factor + tetrahydrobiopterin + O2 | Danio rerio | good substrate | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.16.5 | Caenorhabditis elegans | - |
- |
- |
| 1.14.16.5 | Danio rerio | - |
- |
- |
| 1.14.16.5 | no activity in Drosophila melanogaster | - |
- |
- |
| 1.14.16.5 | Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.14.16.5 | 6-aminohexyl Sepharose column chromatography, diethylaminoethyl cellulose column chromatography, sucrose density centrifugation, and hexadecylglycerol affinity chromatography | Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.16.5 | liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.16.5 | 1-O-alkyl-sn-glycerol 3-phosphate + tetrahydrobiopterin + O2 | - |
Caenorhabditis elegans | 1-O-(1-hydroxyalkyl)-sn-glycerol 3-phosphate + 6,7-[8]-dihydrobiopterin + H2O | - |
? | |
| 1.14.16.5 | 1-O-alkyl-sn-glycerol 3-phosphate + tetrahydrobiopterin + O2 | - |
Danio rerio | 1-O-(1-hydroxyalkyl)-sn-glycerol 3-phosphate + 6,7-[8]-dihydrobiopterin + H2O | - |
? | |
| 1.14.16.5 | 1-O-pyrenedecyl-glycerol + tetrahydrobiopterin + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.16.5 | 1-O-pyrenedecyl-glycerol + tetrahydrobiopterin + O2 | - |
Caenorhabditis elegans | ? | - |
? | |
| 1.14.16.5 | 1-O-pyrenedecyl-glycerol + tetrahydrobiopterin + O2 | - |
Danio rerio | ? | - |
? | |
| 1.14.16.5 | hexadecylglycerol + tetrahydrobiopterin + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.16.5 | hexadecylglycerol + tetrahydrobiopterin + O2 | - |
Caenorhabditis elegans | ? | - |
? | |
| 1.14.16.5 | hexadecylglycerol + tetrahydrobiopterin + O2 | - |
Danio rerio | ? | - |
? | |
| 1.14.16.5 | lyso-alkyl-glycerol phospholipid + tetrahydrobiopterin + O2 | - |
Rattus norvegicus | 1-O-(1-hydroxyalkyl)-sn-glycerol + 6,7-[8]-dihydrobiopterin + H2O | - |
? | |
| 1.14.16.5 | lyso-platelet activating factor + tetrahydrobiopterin + O2 | good substrate | Rattus norvegicus | ? | - |
? | |
| 1.14.16.5 | lyso-platelet activating factor + tetrahydrobiopterin + O2 | good substrate | Caenorhabditis elegans | ? | - |
? | |
| 1.14.16.5 | lyso-platelet activating factor + tetrahydrobiopterin + O2 | good substrate | Danio rerio | ? | - |
? | |
| 1.14.16.5 | additional information | 1-O-alkyl-sn glycerol-3-phosphate is no substrate | Rattus norvegicus | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.14.16.5 | ? | x * 40500, SDS-PAGE | Rattus norvegicus |
| 1.14.16.5 | ? | x * 40500, SDS-PAGE | Caenorhabditis elegans |
| 1.14.16.5 | ? | x * 40500, SDS-PAGE | Danio rerio |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.16.5 | glyceryl ether monooxygenase | - |
Rattus norvegicus |
| 1.14.16.5 | glyceryl ether monooxygenase | - |
Caenorhabditis elegans |
| 1.14.16.5 | glyceryl ether monooxygenase | - |
Danio rerio |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.16.5 | tetrahydrobiopterin | dependent on | Rattus norvegicus | |
| 1.14.16.5 | tetrahydrobiopterin | dependent on | Caenorhabditis elegans | |
| 1.14.16.5 | tetrahydrobiopterin | dependent on | Danio rerio | |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.14.16.5 | physiological function | the enzyme has an anti-inflammatory action by switching off the platelet activating factor signal by irreversible degradation of its lyso form | Rattus norvegicus |
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