Literature summary extracted from

Schmid, F.; Bruhn, S.; Weber, K.; Mittruecker, H.W.; Guse, A.H.
CD38: a NAADP degrading enzyme (2011), FEBS Lett., 585, 3544-3548.

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.4.99.20	Homo sapiens	P28907	bifunctional ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1	-
2.4.99.20	Mus musculus	P56528	bifunctional ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1	-

Synonyms

EC Number	Synonyms	Comment	Organism
2.4.99.20	CD38	-	Mus musculus

General Information

EC Number	General Information	Comment	Organism
2.4.99.20	physiological function	gene silencing of CD38 does not inhibit NAADP synthesis in intact Jurkat T cells. In vitro, both NAADP formation by base-exchange and degradation to 2-phospho adenosine diphosphoribose are efficiently decreased. Thus in vivo CD38 appears to be a NAADP degrading rather than a NAADP forming enzyme	Homo sapiens
2.4.99.20	physiological function	gene silencing of CD38 does not inhibit NAADP synthesis in thymus or spleen obtained from CD38 knock out mice	Mus musculus

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Release 2023.1 (January 2023)