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Literature summary extracted from

  • Nowicki, M.; Müller, F.; Frentzen, M.
    Cardiolipin synthase of Arabidopsis thaliana (2005), FEBS Lett., 579, 2161-2165.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.8.41 overexpression in Escherichia coli Arabidopsis thaliana

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.8.41 Triton X-100 0.2 mM, 50% inhibition. Concentrations higher than 0.6 mM result in an almost complete inhibition Arabidopsis thaliana

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.8.41 0.0014
-
 CDP-dioleoylglycerol pH 8.8, 30°C Arabidopsis thaliana
2.7.8.41 0.15
-
 dioleoylphosphatidylglycerol pH 8.8, 30°C Arabidopsis thaliana

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.8.41 mitochondrion
-
 Arabidopsis thaliana 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.8.41 CoCl2 requires divalent cations for activity. Highest activities are measured in the presence of 20 mM MnCl2, while MgCl2 or CoCl2 stimulate the activity only slightly Arabidopsis thaliana
2.7.8.41 MgCl2 requires divalent cations for activity. Highest activities are measured in the presence of 20 mM MnCl2, while MgCl2 or CoCl2 stimulate the activity only slightly Arabidopsis thaliana
2.7.8.41 MnCl2 requires divalent cations for activity. Highest activities are measured in the presence of 20 mM MnCl2, while MgCl2 or CoCl2 stimulate the activity only slightly Arabidopsis thaliana

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.41 Arabidopsis thaliana Q93YW7
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.8.41 proteolytic modification the preprotein expressed in yeast can be imported into mitochondria and processed to a catalytically active protein Arabidopsis thaliana

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.8.41
-
 Arabidopsis thaliana

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.41 CDP-dioleoylglycerol + dioleoylphosphatidylglycerol the enzyme is less active with phosphatidyl-glycerol species carrying one or two palmitoyl groups than with the dioleoyl species of phosphatidyl-glycerol. In addition, CDP-dipalmitoylglycerol hardly competes with CDP-dioleolyglycerol as substrate Arabidopsis thaliana a cardiolipin + CMP
-
 ?
2.7.8.41 CDP-dioleoylglycerol + dipalmitoylphosphatidylglycerol the enzyme is less active with phosphatidyl-glycerol species carrying one or two palmitoyl groups than with the dioleoyl species of phosphatidyl-glycerol. In addition, CDP-dipalmitoylglycerol hardly competes with CDP-dioleolyglycerol as substrate Arabidopsis thaliana a cardiolipin + CMP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.8.41 At4g04870
-
 Arabidopsis thaliana

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.8.41 30
-
 assay at Arabidopsis thaliana

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.8.41 8.8
-
 assay at Arabidopsis thaliana
2.7.8.41 9
-
-
 Arabidopsis thaliana