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Literature summary extracted from

  • Rausch, S.; Haenchen, A.; Denisiuk, A.; Loehken, M.; Schneider, T.; Suessmuth, R.
    Feglymycin is an inhibitor of the enzymes MurA and MurC of the peptidoglycan biosynthesis pathway (2011), ChemBioChem, 12, 1171-1173.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.2.8 feglymycin isolated from Streptomyces sp. DSM 11171, 13-mer peptide, noncompetitive inhibition, the inhibition is fully reversible after dilution Escherichia coli
6.3.2.8 feglymycin isolated from Streptomyces sp. DSM 11171, 13-mer peptide, noncompetitive inhibition, the inhibition is fully reversible after dilution Staphylococcus aureus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.2.8 ATP + UDP-N-acetylmuramate + L-alanine Staphylococcus aureus
-
 ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine
-
 ?
6.3.2.8 ATP + UDP-N-acetylmuramate + L-alanine Escherichia coli
-
 ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.8 Escherichia coli
-
 gene murC
-
6.3.2.8 Staphylococcus aureus
-
 gene murC
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.8 ATP + UDP-N-acetylmuramate + L-alanine
-
 Staphylococcus aureus ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine
-
 ?
6.3.2.8 ATP + UDP-N-acetylmuramate + L-alanine
-
 Escherichia coli ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.3.2.8 MurC
-
 Staphylococcus aureus
6.3.2.8 MurC
-
 Escherichia coli

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
6.3.2.8 25
-
 assay at Staphylococcus aureus
6.3.2.8 25
-
 assay at Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
6.3.2.8 ATP
-
 Staphylococcus aureus
6.3.2.8 ATP
-
 Escherichia coli

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
6.3.2.8 0.0003
-
 feglymycin pH not specified in the publication, 25°C Escherichia coli
6.3.2.8 0.001
-
 feglymycin pH not specified in the publication, 25°C Staphylococcus aureus