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Literature summary extracted from

  • Liu, Y.; Fang, J.; Cai, H.; Xiao, F.; Ding, K.; Hu, Y.
    Identification and synthesis of substituted pyrrolo[2,3-d]pyrimidines as novel firefly luciferase inhibitors (2012), Bioorg. Med. Chem., 20, 5473-5482.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.12.7 2-([7-(propan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy)aniline
-
 Photinus pyralis
1.13.12.7 3-([7-(propan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy)aniline
-
 Photinus pyralis
1.13.12.7 4-((7-[4-(trifluoromethyl)benzyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)aniline 7% inhibition Photinus pyralis
1.13.12.7 4-(4-aminophenoxy)-7-(propan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine
-
 Photinus pyralis
1.13.12.7 4-(7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)aniline 19% inhibition Photinus pyralis
1.13.12.7 4-([2-(methylsulfanyl)-7-(propan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy)aniline 31% inhibition Photinus pyralis
1.13.12.7 4-([2-(methylsulfonyl)-7-(propan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy)aniline 9% inhibition Photinus pyralis
1.13.12.7 4-([7-(2,2-dimethylpropyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy)-N,N-dimethylaniline
-
 Photinus pyralis
1.13.12.7 4-([7-(2,2-dimethylpropyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy)-N-methylaniline
-
 Photinus pyralis
1.13.12.7 4-([7-(2,2-dimethylpropyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy)aniline
-
 Photinus pyralis
1.13.12.7 4-([7-(2-methylprop-2-en-1-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy)aniline
-
 Photinus pyralis
1.13.12.7 4-([7-(2-methylpropyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy)aniline
-
 Photinus pyralis
1.13.12.7 4-([7-(3-methylbut-2-en-1-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy)aniline
-
 Photinus pyralis
1.13.12.7 4-([7-(3-methylbutyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy)aniline
-
 Photinus pyralis
1.13.12.7 4-([7-(4-methoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy)aniline 26% inhibition Photinus pyralis
1.13.12.7 4-([7-(prop-2-en-1-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy)aniline
-
 Photinus pyralis
1.13.12.7 4-([7-(propan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy)aniline
-
 Photinus pyralis
1.13.12.7 4-[(7-benzyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy]aniline 46% inhibition Photinus pyralis
1.13.12.7 4-[(7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy]aniline
-
 Photinus pyralis
1.13.12.7 4-[(7-ethenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy]aniline
-
 Photinus pyralis
1.13.12.7 4-[(7-ethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy]aniline
-
 Photinus pyralis
1.13.12.7 4-[(7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy]aniline 48% inhibition Photinus pyralis
1.13.12.7 ethyl [4-(4-aminophenoxy)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]acetate 33% inhibition Photinus pyralis
1.13.12.7 N,N-dimethyl-4-([7-(2-methylprop-2-en-1-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy)aniline
-
 Photinus pyralis
1.13.12.7 N,N-dimethyl-4-([7-(propan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy)aniline
-
 Photinus pyralis
1.13.12.7 N-methyl-4-([7-(2-methylprop-2-en-1-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy)aniline
-
 Photinus pyralis
1.13.12.7 N-methyl-4-([7-(propan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy)aniline
-
 Photinus pyralis

Organism

EC Number Organism UniProt Comment Textmining
1.13.12.7 Photinus pyralis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.12.7 D-luciferin + ATP + O2
-
 Photinus pyralis luciferyl-adenylate + diphosphate + H2O + hv
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.12.7 luciferin
-
 Photinus pyralis

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.13.12.7 20
-
 assay at Photinus pyralis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.13.12.7 7.8
-
 assay at Photinus pyralis

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.13.12.7 0.00006
-
 pH 7.8, 20°C Photinus pyralis N-methyl-4-([7-(2-methylprop-2-en-1-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy)aniline
1.13.12.7 0.00007
-
 pH 7.8, 20°C Photinus pyralis 4-([7-(2,2-dimethylpropyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy)-N-methylaniline
1.13.12.7 0.00008
-
 pH 7.8, 20°C Photinus pyralis 4-([7-(2,2-dimethylpropyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy)aniline
1.13.12.7 0.00009
-
 pH 7.8, 20°C Photinus pyralis N,N-dimethyl-4-([7-(2-methylprop-2-en-1-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy)aniline
1.13.12.7 0.00012
-
 pH 7.8, 20°C Photinus pyralis 4-([7-(2,2-dimethylpropyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy)-N,N-dimethylaniline
1.13.12.7 0.00012
-
 pH 7.8, 20°C Photinus pyralis 4-([7-(2-methylprop-2-en-1-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy)aniline
1.13.12.7 0.00013
-
 pH 7.8, 20°C Photinus pyralis N-methyl-4-([7-(propan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy)aniline
1.13.12.7 0.00018
-
 pH 7.8, 20°C Photinus pyralis N,N-dimethyl-4-([7-(propan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy)aniline
1.13.12.7 0.00029
-
 pH 7.8, 20°C Photinus pyralis 4-[(7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy]aniline
1.13.12.7 0.00031
-
 pH 7.8, 20°C Photinus pyralis 4-([7-(2-methylpropyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy)aniline
1.13.12.7 0.00036
-
 pH 7.8, 20°C Photinus pyralis 4-([7-(propan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy)aniline
1.13.12.7 0.00224
-
 pH 7.8, 20°C Photinus pyralis 4-([7-(prop-2-en-1-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy)aniline
1.13.12.7 0.00351
-
 pH 7.8, 20°C Photinus pyralis 4-[(7-ethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy]aniline
1.13.12.7 0.00646
-
 pH 7.8, 20°C Photinus pyralis 4-([7-(3-methylbutyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy)aniline
1.13.12.7 0.0073
-
 pH 7.8, 20°C Photinus pyralis 2-([7-(propan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy)aniline
1.13.12.7 0.00753
-
 pH 7.8, 20°C Photinus pyralis 4-([7-(3-methylbut-2-en-1-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy)aniline
1.13.12.7 0.00943
-
 pH 7.8, 20°C Photinus pyralis 4-[(7-ethenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy]aniline
1.13.12.7 0.01076
-
 pH 7.8, 20°C Photinus pyralis 4-(4-aminophenoxy)-7-(propan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine
1.13.12.7 0.01471
-
 pH 7.8, 20°C Photinus pyralis 3-([7-(propan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy)aniline