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Literature summary extracted from

  • Pal, M.; Bearne, S.L.
    Inhibition of glutamate racemase by substrate-product analogues (2014), Bioorg. Med. Chem. Lett., 24, 1432-1436.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.1.1.3 (R,S)-1-hydroxy-1-oxo-4-amino-4-carboxyphosphorinane
-
 Enterococcus faecalis
5.1.1.3 (R,S)-4-amino-4-carboxy-1,1-dioxotetrahydro-thiopyran
-
 Enterococcus faecalis
5.1.1.3 1,1-dioxo-tetrahydrothiopyran-4-one
-
 Enterococcus faecalis
5.1.1.3 1-hydroxyphosphinan-4-one 1-oxide
-
 Enterococcus faecalis
5.1.1.3 2-amino-4-phosphonobutanoic acid
-
 Enterococcus faecalis
5.1.1.3 bis(2-carboxyethyl)-phosphinic acid
-
 Enterococcus faecalis
5.1.1.3 additional information substrate-product analogue inhibitor synthesis and evaluation, overview Enterococcus faecalis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.1.1.3 L-glutamate Enterococcus faecalis
-
 D-glutamate
-
 r

Organism

EC Number Organism UniProt Comment Textmining
5.1.1.3 Enterococcus faecalis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.1.1.3 L-glutamate
-
 Enterococcus faecalis D-glutamate
-
 r

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
5.1.1.3 3.1
-
 (R,S)-1-hydroxy-1-oxo-4-amino-4-carboxyphosphorinane pH and temperature not specified in the publication Enterococcus faecalis
5.1.1.3 18.4
-
 1,1-dioxo-tetrahydrothiopyran-4-one pH and temperature not specified in the publication Enterococcus faecalis

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
5.1.1.3 21.2
-
 pH and temperature not specified in the publication Enterococcus faecalis 1,1-dioxo-tetrahydrothiopyran-4-one
5.1.1.3 24.1
-
 pH and temperature not specified in the publication Enterococcus faecalis (R,S)-1-hydroxy-1-oxo-4-amino-4-carboxyphosphorinane
5.1.1.3 47.7
-
 pH and temperature not specified in the publication Enterococcus faecalis 1-hydroxyphosphinan-4-one 1-oxide
5.1.1.3 60.4
-
 pH and temperature not specified in the publication Enterococcus faecalis bis(2-carboxyethyl)-phosphinic acid
5.1.1.3 105
-
 pH and temperature not specified in the publication Enterococcus faecalis 2-amino-4-phosphonobutanoic acid
5.1.1.3 215
-
 pH and temperature not specified in the publication Enterococcus faecalis (R,S)-4-amino-4-carboxy-1,1-dioxotetrahydro-thiopyran

General Information

EC Number General Information Comment Organism
5.1.1.3 physiological function D-glutamate is an essential biosynthetic building block of the peptidoglycans that encapsulate the bacterial cell wall Enterococcus faecalis