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Literature summary extracted from

  • Tamai, K.T.; Greenberg, M.L.
    Biochemical characterization and regulation of cardiolipin synthase in Saccharomyces cerevisiae (1990), Biochim. Biophys. Acta, 1046, 214-222.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.8.41 Triton maximal activity is obtained with a Triton X-100:phospholipid ratio of 1:1 Saccharomyces cerevisiae

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.8.41 1,2-dioleoylphosphatidylglycerol above 0.65 mM Saccharomyces cerevisiae
2.7.8.41 CDP-dioleoylglycerol above 0.1 mM Saccharomyces cerevisiae

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.8.41 0.036
-
 CDP-dioleoylglycerol pH 9.0, 45°C Saccharomyces cerevisiae
2.7.8.41 1
-
 1,2-dioleoylphosphatidylglycerol pH 9.0, 45°C Saccharomyces cerevisiae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.8.41 mitochondrion
-
 Saccharomyces cerevisiae 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.8.41 Mg2+ maximal activity is obtained in the presence of 20 mM Mg2+ Saccharomyces cerevisiae

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.41 Saccharomyces cerevisiae Q07560
-
-
2.7.8.41 Saccharomyces cerevisiae ATCC 204508 Q07560
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.41 CDP-dioleoylglycerol + 1,2-dioleoylphosphatidylglycerol
-
 Saccharomyces cerevisiae 1,3-bis(1,2-dioleoyl-sn-glycero-3-phospho)-sn-glycerol + CMP
-
 ?
2.7.8.41 CDP-dioleoylglycerol + 1,2-dioleoylphosphatidylglycerol
-
 Saccharomyces cerevisiae ATCC 204508 1,3-bis(1,2-dioleoyl-sn-glycero-3-phospho)-sn-glycerol + CMP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.8.41 CLS1
-
 Saccharomyces cerevisiae
2.7.8.41 CRD1
-
 Saccharomyces cerevisiae

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.8.41 45
-
-
 Saccharomyces cerevisiae

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
2.7.8.41 35 65 35°C: about 45% of maximal activity, 65°C: about 40% of maximal activity Saccharomyces cerevisiae

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.7.8.41 55
-
 20 min, stable up to Saccharomyces cerevisiae

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.8.41 9
-
-
 Saccharomyces cerevisiae

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.7.8.41 7.5 10 pH 7.5: about 45% of maximal activity, pH 10.0: about 85% of maximal activity Saccharomyces cerevisiae