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Literature summary extracted from

  • Mukha, D.V.; Feranchuk, S.I.; Gilep, A.A.; Usanov, S.A.
    Molecular modeling of human lanosterol 14alpha-demethylase complexes with substrates and their derivatives (2011), Biochemistry, 76, 175-185.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.14.14.154 F145A the mutation leads to a serious weakening of steroid ligand binding Homo sapiens
1.14.14.154 I383A the mutation leads to a serious weakening of steroid ligand binding Homo sapiens
1.14.14.154 R388A the mutation leads to a serious weakening of steroid ligand binding Homo sapiens
1.14.14.154 V149A the mutation leads to a serious weakening of steroid ligand binding Homo sapiens
1.14.14.154 Y137A the mutation leads to a serious weakening of steroid ligand binding Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.154 24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens
-
 24,25-dihydro-4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.154 lanosterol + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens
-
 4,4-dimethylcholesta-8,14,24-trien-3-ol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.154 obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens
-
 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.154 Homo sapiens Q16850
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.154 24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens 24,25-dihydro-4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.154 lanosterol + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens 4,4-dimethylcholesta-8,14,24-trien-3-ol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.154 obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.154 CYP51A1
-
 Homo sapiens
1.14.14.154 lanosterol 14alpha-demethylase
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.14.14.154 metabolism CYP51A1 is involved in the cholesterol biosynthesis pathway Homo sapiens