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Literature summary extracted from

  • Yum, S.; Choi, J.; Hong, S.; Park, M.H.; Lee, J.; Ha, N.C.; Jung, Y.
    Hyperoxia attenuates the inhibitory effect of nitric oxide donors on HIF prolyl-4-hydroxylase-2: Implication on discriminative effect of nitric oxide on HIF prolyl-4-hydroxylase-2 and collagen prolyl-4-hydroxylase (2011), Biochem. Pharmacol., 82, 485-490.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.11.2 S-nitroso-N-acetylpenicillamine hyperoxia attenuates the inhibitory effect of NO on HIF-1alpha prolyl hydroxylation Homo sapiens
1.14.11.2 S-nitrosoglutathione hyperoxia attenuates the inhibitory effect of NO on HIF-1alpha prolyl hydroxylation Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.11.2 A-549 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.2 biotin-Ahx-DLDLEALAP564YIPADDDFQL + 2-oxoglutarate + O2 19mer HIF peptide not containing cysteine is used, in order to rule out an involvement of the cysteine nitrosylation Homo sapiens ?
-
 ?
1.14.11.2 hypoxia-inducible factor L-proline + 2-oxoglutarate + O2
-
 Homo sapiens hypoxia-inducible factor trans-4-hydroxy-L-proline + succinate + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.11.2 HPH-2
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.14.11.2 30
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.11.2 7.5
-
 assay at Homo sapiens