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Literature summary extracted from

  • Marbaix, A.Y.; Tyteca, D.; Niehaus, T.D.; Hanson, A.D.; Linster, C.L.; Van Schaftingen, E.
    Occurrence and subcellular distribution of the NAD(P)HX repair system in mammals (2014), Biochem. J., 460, 49-58.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.1.99.6 gene Aibp, expression of GFP-fused or Myc-tagged mAIBP in CHO cells and in HEK-293 cells, in vitro transcription-translation assays, full-length coding sequences of the mouse mAIBP Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.1.99.6 cytosol
-
 Mus musculus 5829
-
5.1.99.6 cytosol
-
 Rattus norvegicus 5829
-
5.1.99.6 cytosol
-
 Homo sapiens 5829
-
5.1.99.6 mitochondrion mainly Mus musculus 5739
-
5.1.99.6 mitochondrion mainly Rattus norvegicus 5739
-
5.1.99.6 mitochondrion mainly Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.1.99.6 (6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide Mus musculus i.e. NADHX (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide
-
 r
5.1.99.6 (6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide Rattus norvegicus i.e. NADHX (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide
-
 r
5.1.99.6 (6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide Homo sapiens i.e. NADHX (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide
-
 r
5.1.99.6 (6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate Mus musculus i.e. NADPHX (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate
-
 r
5.1.99.6 (6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate Rattus norvegicus i.e. NADPHX (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate
-
 r
5.1.99.6 (6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate Homo sapiens i.e. NADPHX (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate
-
 r

Organism

EC Number Organism UniProt Comment Textmining
5.1.99.6 Homo sapiens Q8NCW5 gene Aibp
-
5.1.99.6 Mus musculus Q8K4Z3 gene Aibp
-
5.1.99.6 Rattus norvegicus B0BNM1 gene Aibp
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.1.99.6 native AIBP protein from liver by anion exchange chromatography Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.1.99.6 liver
-
 Mus musculus
-
5.1.99.6 liver
-
 Rattus norvegicus
-
5.1.99.6 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.1.99.6 (6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide i.e. NADHX Mus musculus (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide
-
 r
5.1.99.6 (6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide i.e. NADHX Rattus norvegicus (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide
-
 r
5.1.99.6 (6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide i.e. NADHX Homo sapiens (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide
-
 r
5.1.99.6 (6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate i.e. NADPHX Mus musculus (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate
-
 r
5.1.99.6 (6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate i.e. NADPHX Rattus norvegicus (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate
-
 r
5.1.99.6 (6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate i.e. NADPHX Homo sapiens (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate
-
 r

Synonyms

EC Number Synonyms Comment Organism
5.1.99.6 AIBP
-
 Mus musculus
5.1.99.6 AIBP
-
 Rattus norvegicus
5.1.99.6 AIBP
-
 Homo sapiens
5.1.99.6 NAD(P)HX epimerase
-
 Mus musculus
5.1.99.6 NAD(P)HX epimerase
-
 Rattus norvegicus
5.1.99.6 NAD(P)HX epimerase
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
5.1.99.6 7.1
-
 assay at Mus musculus
5.1.99.6 7.1
-
 assay at Rattus norvegicus
5.1.99.6 7.1
-
 assay at Homo sapiens

General Information

EC Number General Information Comment Organism
5.1.99.6 physiological function hydration of NAD(P)H to NAD(P)HX, which inhibits several dehydrogenases, is corrected by an ATP-dependent dehydratase and an epimerase recently identified as the products of the vertebrate Carkd (carbohydrate kinase domain) and Aibp (apolipoprotein AI-binding protein) genes, respectively Mus musculus
5.1.99.6 physiological function hydration of NAD(P)H to NAD(P)HX, which inhibits several dehydrogenases, is corrected by an ATP-dependent dehydratase and an epimerase recently identified as the products of the vertebrate Carkd (carbohydrate kinase domain) and Aibp (apolipoprotein AI-binding protein) genes, respectively Rattus norvegicus
5.1.99.6 physiological function hydration of NAD(P)H to NAD(P)HX, which inhibits several dehydrogenases, is corrected by an ATP-dependent dehydratase and an epimerase recently identified as the products of the vertebrate Carkd (carbohydrate kinase domain) and Aibp (apolipoprotein AI-binding protein) genes, respectively Homo sapiens