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Literature summary extracted from

  • Bytyqi-Damoni, A.; Genc, H.; Zengin, M.; Beyaztas, S.; Gencer, N.; Arslan, O.
    In vitro effect of novel beta-lactam compounds on xanthine oxidase enzyme activity (2012), Artif. Cells Blood Substit. Immobil. Biotechnol., 40, 369-377.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.3.2 1-(9-ethyl-9H-carbazol-3-yl)-3,4-diphenylazetidin-2-one
-
 Bos taurus
1.17.3.2 1-(9-ethyl-9H-carbazol-3-yl)-3-phenyl-4-m-totylazetidin-2-one
-
 Bos taurus
1.17.3.2 1-(9-ethyl-9H-carbazol-3-yl)-3-phenyl-4-p-tolylazetidin-2-one
-
 Bos taurus
1.17.3.2 1-(9-ethyl-9H-carbazol-3-yl)-4-(2-nitrophenyl)-3-phenylazetidin-2-one
-
 Bos taurus
1.17.3.2 1-(9-ethyl-9H-carbazol-3-yl)-4-(3-methoxyphenyl)-3-phenylazetidin-2-one
-
 Bos taurus
1.17.3.2 1-(9-ethyl-9H-carbazol-3-yl)-4-(3-nitrophenyl)-3-phenylazetidin-2-one
-
 Bos taurus
1.17.3.2 1-(9-ethyl-9H-carbazol-3-yl)-4-(4-fluorophenyl)-3-phenylazetidin-2-one
-
 Bos taurus
1.17.3.2 1-(9-ethyl-9H-carbazol-3-yl)-4-(4-methoxyphenyl)-3-phenylazetidin-2-one
-
 Bos taurus
1.17.3.2 1-(9-ethyl-9H-carbazol-3-yl)-4-(4-nitrophenyl)-3-phenylazetidin-2-one
-
 Bos taurus
1.17.3.2 4-(2-bromophenyl)-1-(9-ethyl-9H-carbazol-3-yl)-3-phenylazetidin-2-one
-
 Bos taurus
1.17.3.2 4-(3-chlorophenyl)-1-(9-ethyl-9H-carbazol-3-yl)-3-phenylazetidin-2-one
-
 Bos taurus
1.17.3.2 4-(4-chlorophenyl)-1-(9-ethyl-9H-carbazol-3-yl)-3-phenylazetidin-2-one
-
 Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
1.17.3.2 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.17.3.2 ammonium sulfate precipitation and affinity chromatography Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.3.2 xanthine + H2O + O2
-
 Bos taurus uric acid + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.17.3.2 xanthine oxidase
-
 Bos taurus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.17.3.2 37
-
 assay at Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.17.3.2 7.6
-
 assay at Bos taurus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.17.3.2 0.0216
-
 pH 7.6, 37°C Bos taurus 4-(4-chlorophenyl)-1-(9-ethyl-9H-carbazol-3-yl)-3-phenylazetidin-2-one
1.17.3.2 0.0244
-
 pH 7.6, 37°C Bos taurus 1-(9-ethyl-9H-carbazol-3-yl)-4-(3-nitrophenyl)-3-phenylazetidin-2-one
1.17.3.2 0.03037
-
 pH 7.6, 37°C Bos taurus 1-(9-ethyl-9H-carbazol-3-yl)-4-(2-nitrophenyl)-3-phenylazetidin-2-one
1.17.3.2 0.0316
-
 pH 7.6, 37°C Bos taurus 1-(9-ethyl-9H-carbazol-3-yl)-4-(4-methoxyphenyl)-3-phenylazetidin-2-one
1.17.3.2 0.0327
-
 pH 7.6, 37°C Bos taurus 1-(9-ethyl-9H-carbazol-3-yl)-4-(4-nitrophenyl)-3-phenylazetidin-2-one
1.17.3.2 0.03477
-
 pH 7.6, 37°C Bos taurus 1-(9-ethyl-9H-carbazol-3-yl)-3,4-diphenylazetidin-2-one
1.17.3.2 0.0367
-
 pH 7.6, 37°C Bos taurus 1-(9-ethyl-9H-carbazol-3-yl)-3-phenyl-4-m-totylazetidin-2-one
1.17.3.2 0.03808
-
 pH 7.6, 37°C Bos taurus 1-(9-ethyl-9H-carbazol-3-yl)-4-(3-methoxyphenyl)-3-phenylazetidin-2-one
1.17.3.2 0.0386
-
 pH 7.6, 37°C Bos taurus 4-(3-chlorophenyl)-1-(9-ethyl-9H-carbazol-3-yl)-3-phenylazetidin-2-one
1.17.3.2 0.04124
-
 pH 7.6, 37°C Bos taurus 1-(9-ethyl-9H-carbazol-3-yl)-4-(4-fluorophenyl)-3-phenylazetidin-2-one
1.17.3.2 0.04742
-
 pH 7.6, 37°C Bos taurus 1-(9-ethyl-9H-carbazol-3-yl)-3-phenyl-4-p-tolylazetidin-2-one
1.17.3.2 0.05804
-
 pH 7.6, 37°C Bos taurus 4-(2-bromophenyl)-1-(9-ethyl-9H-carbazol-3-yl)-3-phenylazetidin-2-one