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Literature summary extracted from
- Structure-based investigation of rat aldehyde oxidase inhibition by flavonoids (2013), Xenobiotica, 43, 661-670.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.2.3.1 | catechin | - |
Rattus norvegicus |  |
| 1.2.3.1 | daidzein | - |
Rattus norvegicus | |
| 1.2.3.1 | epicatechin | - |
Rattus norvegicus | |
| 1.2.3.1 | genistein | - |
Rattus norvegicus | |
| 1.2.3.1 | hesperetin | - |
Rattus norvegicus | |
| 1.2.3.1 | hesperidin | - |
Rattus norvegicus | |
| 1.2.3.1 | hyperoside | - |
Rattus norvegicus | |
| 1.2.3.1 | menadione | standard aldehyde oxidase inhibitor | Rattus norvegicus | |
| 1.2.3.1 | morin | - |
Rattus norvegicus | |
| 1.2.3.1 | myricetin | - |
Rattus norvegicus | |
| 1.2.3.1 | naringenin | - |
Rattus norvegicus | |
| 1.2.3.1 | quercetin | - |
Rattus norvegicus | |
| 1.2.3.1 | rutin | - |
Rattus norvegicus | |
| 1.2.3.1 | silibinin | - |
Rattus norvegicus | |
| 1.2.3.1 | vitexin | - |
Rattus norvegicus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.2.3.1 | Rattus norvegicus | - |
- |
- |
| 1.2.3.1 | Rattus norvegicus SpragueDawley | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.2.3.1 | partial purification by heat treatment and ammonium sulfate precipitation | Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.2.3.1 | liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.2.3.1 | phenanthridine + H2O + O2 | inhibitory effects of 15 flavonoids on the activity of rat liver aldehyde oxidase assessed, glycosylated flavonoids show relatively weaker inhibition, quantitative structureactivity relationship studies performed to elucidate the important structural properties responsible for the observed inhibitory effects | Rattus norvegicus | ? | - |
? | |
| 1.2.3.1 | phenanthridine + H2O + O2 | inhibitory effects of 15 flavonoids on the activity of rat liver aldehyde oxidase assessed, glycosylated flavonoids show relatively weaker inhibition, quantitative structureactivity relationship studies performed to elucidate the important structural properties responsible for the observed inhibitory effects | Rattus norvegicus SpragueDawley | ? | - |
? | |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 1.2.3.1 | 0.0037 | - |
pH 7.0 and 37°C | Rattus norvegicus | menadione | |
| 1.2.3.1 | 0.00437 | - |
pH 7.0 and 37°C | Rattus norvegicus | quercetin | |
| 1.2.3.1 | 0.00468 | - |
pH 7.0 and 37°C | Rattus norvegicus | genistein | |
| 1.2.3.1 | 0.0049 | - |
pH 7.0 and 37°C | Rattus norvegicus | myricetin | |
| 1.2.3.1 | 0.00933 | - |
pH 7.0 and 37°C | Rattus norvegicus | naringenin | |
| 1.2.3.1 | 0.0123 | - |
pH 7.0 and 37°C | Rattus norvegicus | catechin | |
| 1.2.3.1 | 0.01585 | - |
pH 7.0 and 37°C | Rattus norvegicus | morin | |
| 1.2.3.1 | 0.0166 | - |
pH 7.0 and 37°C | Rattus norvegicus | epicatechin | |
| 1.2.3.1 | 0.01995 | - |
pH 7.0 and 37°C | Rattus norvegicus | hyperoside | |
| 1.2.3.1 | 0.02042 | - |
pH 7.0 and 37°C | Rattus norvegicus | hesperidin | |
| 1.2.3.1 | 0.02399 | - |
pH 7.0 and 37°C | Rattus norvegicus | hesperetin | |
| 1.2.3.1 | 0.02455 | - |
pH 7.0 and 37°C | Rattus norvegicus | daidzein | |
| 1.2.3.1 | 0.0271 | - |
pH 7.0 and 37°C | Rattus norvegicus | rutin | |
| 1.2.3.1 | 0.03802 | - |
pH 7.0 and 37°C | Rattus norvegicus | silibinin | |
| 1.2.3.1 | 0.0389 | - |
pH 7.0 and 37°C | Rattus norvegicus | vitexin | |
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