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Literature summary extracted from

  • Vecchiola, A.; Lagos, C.F.; Fuentes, C.A.; Allende, F.; Campino, C.; Valdivia, C.; Tapia-Castillo, A.; Ogishima, T.; Mukai, K.; Owen, G.; Solari, S.; Carvajal, C.A.; Fardella, C.E.
    Different effects of progesterone and estradiol on chimeric and wild type aldosterone synthase in vitro (2013), Reprod. Biol. Endocrinol., 11, 76.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.15.4 expression of wild-type CYP11B1 and of chimeric mutant CYP11B1/B2 in HEK-293 cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
1.14.15.4 additional information construction of a chimeric mutant from 11beta-hydroxylase CYP11B1 and aldosterone synthase CYP11B2 genes analogously to the naturally occuring mutant resulting from an unequal crossover break point Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.15.4 additional information estradiol has no effect on aldosterone production by wild-type CYP11B1 and chimeric mutant CYP11B1/B2 in HEK-293 cells Homo sapiens
1.14.15.4 progesterone progesterone acts as a competitive inhibitor for 11beta-hydroxylase and aldosterone synthase, inhibits aldosterone production by wild-type CYP11B1 and chimeric mutant CYP11B1/B2 in HEK-293 cells. The wild-type is more strongly inhibited than the chimera Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.14.15.4 Homo sapiens
-
-
-

Synonyms

EC Number Synonyms Comment Organism
1.14.15.4 11beta-hydroxylase
-
 Homo sapiens
1.14.15.4 Aldosterone synthase
-
 Homo sapiens
1.14.15.4 CYP11B1
-
 Homo sapiens
1.14.15.4 CYP11B2
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.15.4 adrenodoxin
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.14.15.4 malfunction familial hyperaldosteronism type I is caused by the unequal recombination between the 11beta-hydroxylase CYP11B1 and aldosterone synthase CYP11B2 genes, resulting in the generation of a CYP11B1/B2 chimeric gene and abnormal adrenal aldosterone production, which leads to severe hypertension and an elevated frequency of stroke at a young age Homo sapiens
1.14.15.4 additional information molecular modelling of CYP11B1 and CYP11B1/B2 chimeric proteins and steroids docking, overview Homo sapiens
1.14.15.4 physiological function progesterone might regulate the 11beta-hydroxylase CYP11B1 and aldosterone synthase CYP11B2 enzymatic activities and contribute to the decay of aldosterone synthase activity in CYP11B1/B2 chimeric gene-positive patients. This regulatory mechanism of progesterone action might be involved in protecting pregnant women with FH-1 against hypertension Homo sapiens