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Literature summary extracted from

  • Sharif, A.; Shoae-Hassani, A.; Sharif, S.; Banafshe, H.R.; Mortazavi-Tabatabaei, S.A.; Verdi, J.
    5alpha-reductase 1 regulates spinal cord testosterone after morphine administration (2013), Neurol. Sci., 34, 19-23.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.3.1.22 morphine morphine significantly reduces the testosterone concentration after acute and chronic exposure in the spinal cord. In contrast, the 5alpha-reductase 1 expression and of course dihydrotestosterone levels increase tfollowing chronic morphine administration Rattus norvegicus

Application

EC Number Application Comment Organism
1.3.1.22 medicine morphine significantly reduces the testosterone concentration after acute and chronic exposure in the spinal cord. In contrast, the 5alpha-reductase 1 expression and of course dihydrotestosterone levels increase the following chronic morphine administration Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.22 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.22 spinal cord
-
 Rattus norvegicus
-

Expression

EC Number Organism Comment Expression
1.3.1.22 Rattus norvegicus morphine significantly reduces the testosterone concentration after acute and chronic exposure in the spinal cord. In contrast, the 5alpha-reductase 1 expression and of course dihydrotestosterone levels increase the following chronic morphine administration up