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Literature summary extracted from

  • Pagotto, M.; Roldan, M.; Pagotto, R.; Lugano, M.; Pisani, G.; Rogic, G.; Molinas, S.; Trumper, L.; Pignataro, O.; Monasterolo, L.
    Localization and functional activity of cytochrome P450 side chain cleavage enzyme (CYP11A1) in the adult rat kidney (2011), Mol. Cell. Endocrinol., 332, 253-260.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.15.6 mitochondrial inner membrane
-
 Rattus norvegicus 5743
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.15.6 (20R,22R)-20,22-dihydroxy-cholesterol + 2 reduced adrenodoxin + O2 Rattus norvegicus
-
 pregnenolone + 4-methylpentanal + 2 oxidized adrenodoxin + 2 H2O
-
 ?
1.14.15.6 (20R,22R)-20,22-dihydroxy-cholesterol + 2 reduced adrenodoxin + O2 Rattus norvegicus Wistar
-
 pregnenolone + 4-methylpentanal + 2 oxidized adrenodoxin + 2 H2O
-
 ?
1.14.15.6 (22R)-22-hydroxycholesterol + 2 reduced adrenodoxin + O2 Rattus norvegicus
-
 (20R,22R)-20,22-dihydroxycholesterol + 2 oxidized adrenodoxin + H2O
-
 ?
1.14.15.6 (22R)-22-hydroxycholesterol + 2 reduced adrenodoxin + O2 Rattus norvegicus Wistar
-
 (20R,22R)-20,22-dihydroxycholesterol + 2 oxidized adrenodoxin + H2O
-
 ?
1.14.15.6 cholesterol + 2 reduced adrenodoxin + O2 Rattus norvegicus
-
 (22R)-22-hydroxycholesterol + 2 oxidized adrenodoxin + H2O
-
 ?
1.14.15.6 cholesterol + 2 reduced adrenodoxin + O2 Rattus norvegicus Wistar
-
 (22R)-22-hydroxycholesterol + 2 oxidized adrenodoxin + H2O
-
 ?
1.14.15.6 cholesterol + 6 reduced adrenodoxin + 3 O2 Rattus norvegicus overall reaction pregnenolone + 4-methylpentanal + 6 oxidized adrenodoxin + 4 H2O
-
 ?
1.14.15.6 cholesterol + 6 reduced adrenodoxin + 3 O2 Rattus norvegicus Wistar overall reaction pregnenolone + 4-methylpentanal + 6 oxidized adrenodoxin + 4 H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.15.6 Rattus norvegicus
-
-
-
1.14.15.6 Rattus norvegicus Wistar
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.15.6 native enzyme partially by purification of mitochondrial inner membranes Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.15.6 kidney renal cortex and medulla, distal convoluted tubule, and thick ascending limb of Henle's loop. The enzyme expression is higher in medulla than in cortex Rattus norvegicus
-
1.14.15.6 additional information Immunohistochemical localization analysis Rattus norvegicus
-
1.14.15.6 renal cortex
-
 Rattus norvegicus
-
1.14.15.6 renal medulla
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.15.6 (20R,22R)-20,22-dihydroxy-cholesterol + 2 reduced adrenodoxin + O2
-
 Rattus norvegicus pregnenolone + 4-methylpentanal + 2 oxidized adrenodoxin + 2 H2O
-
 ?
1.14.15.6 (20R,22R)-20,22-dihydroxy-cholesterol + 2 reduced adrenodoxin + O2
-
 Rattus norvegicus Wistar pregnenolone + 4-methylpentanal + 2 oxidized adrenodoxin + 2 H2O
-
 ?
1.14.15.6 (22R)-22-hydroxycholesterol + 2 reduced adrenodoxin + O2
-
 Rattus norvegicus (20R,22R)-20,22-dihydroxycholesterol + 2 oxidized adrenodoxin + H2O
-
 ?
1.14.15.6 (22R)-22-hydroxycholesterol + 2 reduced adrenodoxin + O2
-
 Rattus norvegicus Wistar (20R,22R)-20,22-dihydroxycholesterol + 2 oxidized adrenodoxin + H2O
-
 ?
1.14.15.6 cholesterol + 2 reduced adrenodoxin + O2
-
 Rattus norvegicus (22R)-22-hydroxycholesterol + 2 oxidized adrenodoxin + H2O
-
 ?
1.14.15.6 cholesterol + 2 reduced adrenodoxin + O2
-
 Rattus norvegicus Wistar (22R)-22-hydroxycholesterol + 2 oxidized adrenodoxin + H2O
-
 ?
1.14.15.6 cholesterol + 6 reduced adrenodoxin + 3 O2 overall reaction Rattus norvegicus pregnenolone + 4-methylpentanal + 6 oxidized adrenodoxin + 4 H2O
-
 ?
1.14.15.6 cholesterol + 6 reduced adrenodoxin + 3 O2 overall reaction Rattus norvegicus Wistar pregnenolone + 4-methylpentanal + 6 oxidized adrenodoxin + 4 H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.15.6 CYP11A1
-
 Rattus norvegicus
1.14.15.6 cytochrome P450 side chain cleavage enzyme
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.15.6 adrenodoxin
-
 Rattus norvegicus
1.14.15.6 cytochrome P450
-
 Rattus norvegicus