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Literature summary extracted from

  • Ji, H.; Das, T.K.; Puustinen, A.; Wikstroem, M.; Yeh, S.R.; Rousseau, D.L.
    Modulation of the active site conformation by site-directed mutagenesis in cytochrome c oxidase from Paracoccus denitrificans (2010), J. Inorg. Biochem., 104, 318-323.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
7.1.1.9 I347Q 16% activity compared to the wild type enzyme Paracoccus denitrificans
7.1.1.9 R473Q 16% activity compared to the wild type enzyme Paracoccus denitrificans
7.1.1.9 R474Q 41% activity compared to the wild type enzyme Paracoccus denitrificans
7.1.1.9 T50A 90% activity compared to the wild type enzyme Paracoccus denitrificans
7.1.1.9 T50N 50% activity compared to the wild type enzyme Paracoccus denitrificans
7.1.1.9 V279I 50% activity compared to the wild type enzyme Paracoccus denitrificans
7.1.1.9 Y339F 64% activity compared to the wild type enzyme Paracoccus denitrificans
7.1.1.9 Y406F 40% activity compared to the wild type enzyme Paracoccus denitrificans

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
7.1.1.9 copper contains copper Paracoccus denitrificans
7.1.1.9 Iron contains iron Paracoccus denitrificans

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.9 Paracoccus denitrificans
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.1.9 oxidized horse heart cytochrome c + H2O
-
 Paracoccus denitrificans reduced horse heart cytochrome c + O2 + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.1.1.9 CCO
-
 Paracoccus denitrificans
7.1.1.9 cytochrome c oxidase
-
 Paracoccus denitrificans

Cofactor

EC Number Cofactor Comment Organism Structure
7.1.1.9 heme a
-
 Paracoccus denitrificans
7.1.1.9 Heme a3
-
 Paracoccus denitrificans