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Literature summary extracted from

  • Valanne, S.; Myllymaeki, H.; Kallio, J.; Schmid, M.R.; Kleino, A.; Murumaegi, A.; Airaksinen, L.; Kotipelto, T.; Kaustio, M.; Ulvila, J.; Esfahani, S.S.; Engstroem, Y.; Silvennoinen, O.; Hultmark, D.; Parikka, M.; Raemet, M.
    Genome-wide RNA interference in Drosophila cells identifies G protein-coupled receptor kinase 2 as a conserved regulator of NF-kappaB signaling (2010), J. Immunol., 184, 6188-6198.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.15 cell membrane
-
 Drosophila melanogaster
-
-
2.7.11.15 cell membrane
-
 Homo sapiens
-
-
2.7.11.15 cytoplasm
-
 Drosophila melanogaster 5737
-
2.7.11.15 cytoplasm
-
 Homo sapiens 5737
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.15 additional information Drosophila melanogaster Gprk2 interacts with the Drosophila IkB homolog Cactus ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.15 Danio rerio
-
-
-
2.7.11.15 Drosophila melanogaster
-
-
-
2.7.11.15 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.15 HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.15 additional information Gprk2 interacts with the Drosophila IkB homolog Cactus Drosophila melanogaster ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.15 Gprk2
-
 Drosophila melanogaster
2.7.11.15 GRK5
-
 Homo sapiens
2.7.11.15 GRK5
-
 Danio rerio

General Information

EC Number General Information Comment Organism
2.7.11.15 malfunction morpholino silencing of the zebrafish ortholog of Gprk2 in fish embryos causes impaired cytokine expression after Escherichia coli infection Danio rerio
2.7.11.15 malfunction RNA silencing of GRK5 in HeLa cells impairs NF-kappaB reporter activity Homo sapiens
2.7.11.15 malfunction using a genome-wide RNAi screen Grk2 is identified as a conserved regulator of NF-kappaB signaling Drosophila melanogaster