EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
4.1.1.48 | E210Q | kcat/Km for 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate is 6fold lower than wild-type value | Saccharolobus solfataricus |
4.1.1.48 | E51Q | kcat/Km for 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate is 28fold lower than wild-type value | Saccharolobus solfataricus |
4.1.1.48 | K53Q | low activity, kcat is 570fold lower than wild-type value | Saccharolobus solfataricus |
4.1.1.48 | K53R | kcat/Km for 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate is 500fold lower than wild-type value | Saccharolobus solfataricus |
4.1.1.48 | R182A | kcat/Km for 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate is 39fold lower than wild-type value | Saccharolobus solfataricus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
4.1.1.48 | 0.000013 | - |
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | pH 7.5, 75°C, mutant enzyme E51Q | Saccharolobus solfataricus | |
4.1.1.48 | 0.000044 | - |
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | pH 7.5, 75°C, wild-type enzyme | Saccharolobus solfataricus | |
4.1.1.48 | 0.000386 | - |
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | pH 7.5, 75°C, mutant enzyme E210Q | Saccharolobus solfataricus | |
4.1.1.48 | 0.00106 | - |
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | pH 7.5, 75°C, mutant enzyme R182A | Saccharolobus solfataricus | |
4.1.1.48 | 0.00244 | - |
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | pH 7.5, 75°C, mutant enzyme K53R | Saccharolobus solfataricus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
4.1.1.48 | Saccharolobus solfataricus | Q06121 | - |
- |
4.1.1.48 | Saccharolobus solfataricus P2 | Q06121 | - |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
4.1.1.48 | - |
Saccharolobus solfataricus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.1.1.48 | 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | Lys53 acts as the general acid in the dehydration step of the reaction | Saccharolobus solfataricus | 1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O | - |
? | |
4.1.1.48 | 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | Lys53 acts as the general acid in the dehydration step of the reaction | Saccharolobus solfataricus P2 | 1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
4.1.1.48 | IGPS | - |
Saccharolobus solfataricus |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
4.1.1.48 | 75 | - |
assay | Saccharolobus solfataricus |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
4.1.1.48 | 0.001 | - |
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | pH 7.5, 75°C, mutant enzyme K53Q | Saccharolobus solfataricus | |
4.1.1.48 | 0.007 | - |
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | pH 7.5, 75°C, mutant enzyme E51Q | Saccharolobus solfataricus | |
4.1.1.48 | 0.06 | - |
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | pH 7.5, 75°C, mutant enzyme K53R | Saccharolobus solfataricus | |
4.1.1.48 | 0.41 | - |
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | pH 7.5, 75°C, mutant enzyme R182A | Saccharolobus solfataricus | |
4.1.1.48 | 0.67 | - |
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | pH 7.5, 75°C, wild-type enzyme | Saccharolobus solfataricus | |
4.1.1.48 | 0.97 | - |
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | pH 7.5, 75°C, mutant enzyme E210Q | Saccharolobus solfataricus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
4.1.1.48 | 7.5 | - |
assay at | Saccharolobus solfataricus |
EC Number | kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
4.1.1.48 | 30 | - |
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | pH 7.5, 75°C, mutant enzyme K53R | Saccharolobus solfataricus | |
4.1.1.48 | 380 | - |
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | pH 7.5, 75°C, mutant enzyme R182A | Saccharolobus solfataricus | |
4.1.1.48 | 540 | - |
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | pH 7.5, 75°C, mutant enzyme E51Q | Saccharolobus solfataricus | |
4.1.1.48 | 2500 | - |
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | pH 7.5, 75°C, mutant enzyme E210Q | Saccharolobus solfataricus | |
4.1.1.48 | 15230 | - |
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | pH 7.5, 75°C, wild-type enzyme | Saccharolobus solfataricus |