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Literature summary extracted from

  • Vitturi, D.A.; Chen, C.S.; Woodcock, S.R.; Salvatore, S.R.; Bonacci, G.; Koenitzer, J.R.; Stewart, N.A.; Wakabayashi, N.; Kensler, T.W.; Freeman, B.A.; Schopfer, F.J.
    Modulation of nitro-fatty acid signaling: prostaglandin reductase-1 is a nitroalkene reductase (2013), J. Biol. Chem., 288, 25626-25637.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.1.16 expression in HEK-293T cell Homo sapiens
1.3.1.16 expression in HEK-293T cell Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3.1.16 0.000085
-
 (9E)-9-nitrooctadec-9-enoic acid pH 7.0, temperature not specified in the publication Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.16 Homo sapiens
-
-
-
1.3.1.16 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.16 liver
-
 Homo sapiens
-
1.3.1.16 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.16 (9E)-9-nitrooctadec-9-enoic acid + NADPH + H+
-
 Homo sapiens 9-nitrostearic acid + NADP+
-
 r
1.3.1.16 10-nitrooctadec-9-enoic acid + NADPH + H+
-
 Homo sapiens 10-nitrostearic acid + NADP+
-
 ?
1.3.1.16 10-nitrooctadec-9-enoic acid + NADPH + H+
-
 Rattus norvegicus 10-nitrostearic acid + NADP+
-
 ?
1.3.1.16 9-nitrooctadec-9-enoic acid + NADPH + H+
-
 Homo sapiens 9-nitrostearic acid + NADP+
-
 ?
1.3.1.16 9-nitrooctadec-9-enoic acid + NADPH + H+
-
 Rattus norvegicus 9-nitrostearic acid + NADP+
-
 ?
1.3.1.16 additional information enzyme is specific for the reduction of the nitroalkene moiety, yielding saturated non-electrophilic products Homo sapiens ?
-
 ?
1.3.1.16 additional information enzyme is specific for the reduction of the nitroalkene moiety, yielding saturated non-electrophilic products Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.16 prostaglandin reductase-1
-
 Homo sapiens
1.3.1.16 prostaglandin reductase-1
-
 Rattus norvegicus
1.3.1.16 PtGR-1
-
 Homo sapiens
1.3.1.16 PtGR-1
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.16 NADH NADPH is preferred over NADH Homo sapiens
1.3.1.16 NADH NADPH is preferred over NADH Rattus norvegicus
1.3.1.16 NADPH NADPH is preferred over NADH Homo sapiens
1.3.1.16 NADPH NADPH is preferred over NADH Rattus norvegicus

General Information

EC Number General Information Comment Organism
1.3.1.16 physiological function overexpression of prostaglandin reductase-1 in HEK-293T cells promotes nitroalkene metabolism to inactive nitroalkanes, an effect that abrogates the Nrf2-dependent induction of heme oxygenase-1 expression by nitro-oleic acid Homo sapiens
1.3.1.16 physiological function overexpression of prostaglandin reductase-1 in HEK-293T cells promotes nitroalkene metabolism to inactive nitroalkanes, an effect that abrogates the Nrf2-dependent induction of heme oxygenase-1 expression by nitro-oleic acid Rattus norvegicus

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
1.3.1.16 81
-
 (9E)-9-nitrooctadec-9-enoic acid pH 7.0, temperature not specified in the publication Homo sapiens