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Literature summary extracted from

  • Ipenberg, I.; Guttmann-Raviv, N.; Khoury, H.P.; Kupershmit, I.; Ayoub, N.
    Heat shock protein 90 (Hsp90) selectively regulates the stability of KDM4B/JMJD2B histone demethylase (2013), J. Biol. Chem., 288, 14681-14687.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.11.66 expression of functional doxycycline-inducible EGFP-KDM4B in U2-OSTetON cell line Homo sapiens

General Stability

EC Number General Stability Organism
1.14.11.66 the molecular chaperon Hsp90 interacts with and stabilizes KDM4B protein Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.11.66 additional information pharmacological inhibition of Hsp90 promotes ubiquitin-dependent proteasomal degradation of KDM4B. Hsp90 inhibition promotes KDM4B degradation and alters the methylation of H3K9 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.11.66 nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.11.66 histone H3 N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 Homo sapiens
-
 histone H3 N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.66 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.11.66 carcinoma cell levels of KDM4B histone demethylase are elevated in different types of cancer cells Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.66 histone H3 N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2
-
 Homo sapiens histone H3 N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.11.66 KDM4B/JMJD2B histone demethylase
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.14.11.66 evolution the enzyme belongs to the family of KDM4A-D histone demethylases Homo sapiens
1.14.11.66 malfunction enzyme depletion suppresses tumor formation Homo sapiens
1.14.11.66 additional information the molecular chaperon Hsp90 interacts with and stabilizes KDM4B protein, pharmacological inhibition of Hsp90 promotes ubiquitin-dependent proteasomal degradation of KDM4B, but not of KDM4C, suggesting that the turnover of these demethylases is regulated by distinct mechanisms, degradation is accompanied by increased methylation of H3K9. Hsp90 inhibition promotes KDM4B degradation and alters the methylation of H3K9 Homo sapiens
1.14.11.66 physiological function KDM4A-D histone demethylases selectively demethylates H3K9 and H3K36 and is implicated in key cellular processes including DNA damage response, transcription, cell cycle regulation, cellular differentiation, senescence, and carcinogenesis Homo sapiens