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Literature summary extracted from

  • Millerioux, Y.; Morand, P.; Biran, M.; Mazet, M.; Moreau, P.; Wargnies, M.; Ebikeme, C.; Deramchia, K.; Gales, L.; Portais, J.C.; Boshart, M.; Franconi, J.M.; Bringaud, F.
    ATP synthesis-coupled and -uncoupled acetate production from acetyl-CoA by mitochondrial acetate:succinate CoA-transferase and acetyl-CoA thioesterase in Trypanosoma (2012), J. Biol. Chem., 287, 17186-17197.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.8.3.8 mitochondrion
-
 Trypanosoma brucei 5739
-

Organism

EC Number Organism UniProt Comment Textmining
2.8.3.8 Trypanosoma brucei
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.3.8 succinate + acetyl-CoA
-
 Trypanosoma brucei acetate + succinyl-CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.3.8 acetate:succinate CoA-transferase
-
 Trypanosoma brucei
2.8.3.8 ASCT
-
 Trypanosoma brucei

General Information

EC Number General Information Comment Organism
2.8.3.8 malfunction the acetate:succinate CoA-transferase null mutant is about 1000times more sensitive to oligomycin, a specific inhibitor of the mitochondrial F0/F1-ATP synthase, than wild type cells Trypanosoma brucei
2.8.3.8 metabolism the enzyme is involved in ATP production in the mitochondrion Trypanosoma brucei