Literature summary extracted from

Garcin, E.B.; Bornet, O.; Elantak, L.; Vita, N.; Pieulle, L.; Guerlesquin, F.; Sebban-Kreuzer, C.
Structural and mechanistic insights into unusual thiol disulfide oxidoreductase (2012), J. Biol. Chem., 287, 1688-1697.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
1.8.4.2	expressed in Escherichia coli TG1 and Rosetta-gami cells	Desulfovibrio vulgaris

Protein Variants

EC Number	Protein Variants	Comment	Organism
1.8.4.2	H33G	the mutant shows a loss of the capacity of the protein to isomerize, or shuffle, incorrect disulfides of scrambled RNase A yielding 10% active RNase A only	Desulfovibrio vulgaris

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
1.8.4.2	cytoplasm	-	Desulfovibrio vulgaris	5737	-

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.8.4.2	GSH + protein-disulfide	Desulfovibrio vulgaris	-	GSSG + protein-dithiol	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.8.4.2	Desulfovibrio vulgaris	-	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
1.8.4.2	nickel-nitrilotriacetic acid column chromatography	Desulfovibrio vulgaris

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.8.4.2	GSH + 5,5'-dithiobis(nitrobenzoic acid)	-	Desulfovibrio vulgaris	?	-	?
1.8.4.2	GSH + protein-disulfide	-	Desulfovibrio vulgaris	GSSG + protein-dithiol	-	?
1.8.4.2	additional information	the enzyme is unable to reduce insulin	Desulfovibrio vulgaris	?	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.8.4.2	desulfothioredoxin	-	Desulfovibrio vulgaris
1.8.4.2	Dtrx	-	Desulfovibrio vulgaris
1.8.4.2	TDOR	-	Desulfovibrio vulgaris
1.8.4.2	thiol disulfide oxidoreductase	-	Desulfovibrio vulgaris

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Release 2023.1 (January 2023)