Literature summary extracted from

Charvet, C.; Liao, W.L.; Heo, G.Y.; Laird, J.; Salomon, R.G.; Turko, I.V.; Pikuleva, I.A.
Isolevuglandins and mitochondrial enzymes in the retina: mass spectrometry detection of post-translational modification of sterol-metabolizing CYP27A1 (2011), J. Biol. Chem., 286, 20413-20422.

Application

EC Number	Application	Comment	Organism
1.14.15.15	medicine	treatment of enzyme with iso[4]levuglandin E2 in vitro diminishes enzyme activity. Lys residues Lys134, Lys358, and Lys476, readily interact iso[4]levuglandin E2 in vitro, and modified CYP27A1 is present in the retina. The post-translational modifications may exemplify a general mechanism whereby oxidative stress and inflammation deleteriously affect protein function, contributing, for example, to cholesterol-rich lesions associated with age-related macular degeneration and cardiovascular disease	Bos taurus

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
1.14.15.15	mitochondrion	-	Bos taurus	5739	-

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.14.15.15	Bos taurus	-	-	-

Posttranslational Modification

EC Number	Posttranslational Modification	Comment	Organism
1.14.15.15	side-chain modification	treatment of enzyme with iso[4]levuglandin E2 in vitro diminishes enzyme activity. Lys residues Lys134, Lys358, and Lys476, readily interact iso[4]levuglandin E2 in vitro, and modified CYP27A1 is present in the retina	Bos taurus

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.14.15.15	retina	-	Bos taurus	-

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Release 2023.1 (January 2023)