EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.14.14.14 | 19-hydroxyandrost-4-ene-3,17-dione | competitively inhibits the formation of 19-hydroxyandrost-4-ene-3,17-dione and estrogen | Homo sapiens | |
1.14.14.14 | 19-oxoandrost-4-ene-3,17-dione | competitively inhibits the formation of 19-oxoandrost-4-ene-3,17-dione and estrogen | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.14.14 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.14.14.14 | placenta | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.14.14 | 19-hydroxyandrost-4-ene-3,17-dione + O2 + a reduced flavoprotein | - |
Homo sapiens | 19-oxo-androst-4-ene-3,17-dione + 2 H2O + an oxidized flavoprotein | - |
? | |
1.14.14.14 | 19-oxoandrost-4-ene-3,17-dione + O2 + a reduced flavoprotein | - |
Homo sapiens | estrone + formate + H2O + an oxidized flavoprotein | - |
? | |
1.14.14.14 | androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins | - |
Homo sapiens | estrone + formate + 4 H2O + 3 oxidized flavoproteins | overall reaction | ? | |
1.14.14.14 | androst-4-ene-3,17-dione + O2 + a reduced flavoprotein | - |
Homo sapiens | 19-hydroxyandrost-4-ene-3,17-dione + H2O + an oxidized flavoprotein | - |
? | |
1.14.14.14 | additional information | the aromatization of androstenedione probably involves two successive hydroxylations at the C-19 methyl group, mediated by a common catalytic site with the third and rate-determining 2beta-hydroxylation taking place at a different enzyme site | Homo sapiens | ? | - |
? |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.14.14.14 | 0.00038 | - |
19-hydroxyandrost-4-ene-3,17-dione | substrate 19-oxoandrost-4-ene-3,17-dione, pH 7.0, 37°C | Homo sapiens | |
1.14.14.14 | 0.00045 | - |
19-hydroxyandrost-4-ene-3,17-dione | substrate androst-4-ene-3,17-dione, pH 7.0, 37°C | Homo sapiens | |
1.14.14.14 | 0.0015 | - |
19-oxoandrost-4-ene-3,17-dione | substrate 19-hydroxyandrost-4-ene-3,17-dione, pH 7.0, 37°C | Homo sapiens | |
1.14.14.14 | 0.003 | - |
19-oxoandrost-4-ene-3,17-dione | substrate androst-4-ene-3,17-dione, pH 7.0, 37°C | Homo sapiens |